Institute of Nuclear Energy Research

Gann Ting

Shui-Tein Chen

Lie-Hang Shen

Te-Wei Lee

Shyh-Yi Chyi

Zei-Tsan Tsai

Shiang-Rong Chang

Tsai-Shu Kuo

Tian-Fu Huang

Chang-Mau Shing

Kung-Tsung Wang

Sheng-Laang Chern

Sir-Sea Chang

Hsiao-Ming Chen

Ying-Ming Tsai

This invention is a novel synthesis of BCA-peptides (BCA: bifunctional chelating agents). In this method, the starting material--Fmoc-Thr(ol)-Terephthal-Acetal-Amide Resin is coupled with the various amino acids. The straight peptide-resin of D-Phe-Cys(Trt)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)-Terephtha l-Acetal-Amide Resin was obtained. This compound reacted with iodine to give disulfide-containing peptide resin of ##STR1## Cleavage of the peptide from the resin was achieved by TFA. The cleavaged peptide was protected by the reaction of octreotide with di-t-butyldicarbonate. BCA was coupled to the selectively protected octreotide. This product was obtained by reaction of protected BCA-peptides with TFA. The final product was labeled by radioisotope .sup.111 InCl.sub.3 for tumor imaging radiopharmaceuticals.

Method for synthesis of bifunctional chelating agents-peptides

A synergistic extractant combination consisting of di(2-ethylhexyl) phosphoric acid (D2EHPA) and dibutyl butyl phosphonate (DBBP) in kerosene is employed in a two-cycle separation process for the recovery of uranium from wet-process phosphoric acid. The addition of the sulfuric acid and water scrubbing steps for the recycled extractant provides no disadvantages with respect to the comtamination and dilution by the ammonium ion and water to the phosphoric acid and also no precipitation occurs in the second cycle extraction step. The advantages of this process are lower chemical cost, higher product purity and better phase separation in comparison with the previous process.

Separation process for the recovery of uranium from wet-process

In the process of uranium recovery from wet-process phosphoric acid, post treatment of the raffinate phosphoric acid is very important to prevent damage to the rubber linings of the acid evaporators and to recover the solvent for reuse. A simple and continuous method using an inclined parallel-corrugated-plate separator to remove the organic solvent entrainment from the raffinate phosphoric acid is established herein.

Post treatment method for the recovery of uranium from wet-process

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Gann Ting