Aurobindo Pharma Limited

Gangadhara Bhima Shankar Nangi

Sivakumaran Meenakshisunderam

Sukumar Nandi

Sambhu Prasad Sarma Mallela

Venkata Rama Krishna Murthy Moturu

Shankar Reddy Budidet

Rani Ananta

Islam Aminul

Raveendra Reddy Chinta

Jyothi Sudharshan Chakradhar Saladi

Sadashiv Jagtap

Mahendar Reddy Nayini

Ramadas Chavakula

Somappa Somannavar Yallapa

Sandeep Kumar Vadla

The present invention relates to a process for the preparation of Trametinib acetic acid solvate (Ia): The present invention also directed towards a pharmaceutical composition comprising Trametinib acetic acid solvate (Ia) and optionally one or more pharmaceutically acceptable excipients or carriers.

Process for the preparation of trametinib acetic acid solvate

The present invention relates to a process for the preparation of pure Valsartan (I) substantially free from impurities of formulae (Ia), (Ib), and (Ic), which comprises: (i) condensing 2-(4'-bromomethylphenyl)benzonitrile of formula (II) with L-valine methyl ester hydrochloride of formula (V) in the presence of a base in a solvent to produce N-[(2&#x2032;-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester of formula (VI); (ii) treating the compound VI of step (i) with acid followed by treating with base to produce pure compound VI substantially free from dimeric impurity of formula (Via); (iii) reacting the pure compound of formula (VI) with n-valeryl chloride in the presence of a base to produce pure N-valeryl-N-[(2&#x2032;-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester (VII) substantially free from alkene impurity of formula (Vila); (iv) reacting the compound of formula (VII) with trialkyltin chloride and a metal azide in a solvent at a reflux temperature to produce N-(1-oxopentyl)-N-[[2&#x2032;-(2-tributyltintetrazol-5-yl)-(1,1&#x2032;-biphenyl)-4-yl]methyl]-(L)-valine methyl ester of formula (VHIb) free from thermal degradation impurity (Villa); (v) hydrolyzing the compound of formula (VHIb) in the presence of alkaline conditions to produce Valsartan (I).

Process for the preparation of valsartan

The present invention relates to an improved process for preparing (2E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-propenal of formula (I), which is an useful intermediate in the preparation of Rosuvastatin. 

Process for preparing pyrimidine propenaldehyde

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Hyderabad Telangana, India

Gangadhara Bhima Shankar Nangi