Suzhou Ark Biopharmaceutical Co., Ltd.

Fujitsu Corporation

Gang Zou

Yang Zhou

Zhen Jim Wu

Haiqing Yuan

Cheng Peng

Xiaogang Lai

Shaoyun Zhang

Danbin Li

Xiashi Lv

Zhaoxiong Cai

Kanji Uchino

Jun Wang

Mengfei Qian

Yanfei Wang

Qing Xu

Teng Feng

Rui Cui

Jian Han

Chaojun Gong

The present disclosure provides an elastase inhibitor prodrug and use thereof, being a compound of formula I or a pharmaceutically acceptable salt, ester, isomer or solvate thereof, prodrugs or isotopically labeled compound. Compared with the compound 52 (control example) in WO 2018/175173 A1, the compound disclosed herein has the advantages of high pulmonary exposure and long half-life. The prodrugs of the present disclosure significantly increase the concentration and residence time of the active compound (control example) in the lungs with significant improvements in pharmacokinetics in vivo compared to the control example.

Elastase inhibitor prodrug and use thereof

In an embodiment, operations include crawling a set of web pages and labeling one or more items of a first web page based on user input. Each item corresponds to a node in a first tree data structure of the first web page. The operations further include generating a first extraction rule to extract a first item from the one or more first items. The first extraction rule includes a first path, in the first tree data structure, for a first node of the first item, and includes first visual information of each node in the first path. The operations further include comparing the first visual information in the first path with second visual information of each of a plurality of candidate nodes in a second tree data structure of a second web page and further refining the first extraction rule to generate a second extraction rule.

Enhanced information extraction from web pages

Compositions containing the compound of general formula I: are disclosed. The compositions be used to prevent or treat hepatitis B virus infection.

Dihydroisoquinoline compound

A compound of general formula I: is disclosed. The compound be used to prevent or treat hepatitis B virus infection.

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Suzhou, China

Gang Zou