Nitto-denko Corporation

Isis Pharmaceuticals, Inc.

Gang Zhao

Lei Yu

Sang Van

Xiaoli Fu

Jian Liu

Xinghe Wang

Chieko Kitaura

Zhongling Feng

Vasulinga T Ravikumar

Tatsuya Konishi

Zheng Hou

Raju K Kumar

Yucheng Song

Ayako Matsunawa

Takeo Matsumura

Kenjirou Mori

Cheiko Kitaura

Yoshiro Niitsu

Yi Jin

Yasunobu Tanaka

Fu Chen

Nianchun Ma

Chris Castello

Sanjib Kumar Das

Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

Polyglutamate-amino acid conjugates and methods

Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

Compositions that include a hydrophobic compound and a polyamino acid conjugate

Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The transmembrane transporter compounds may include peptide nucleic acid monomer units.

Peptide nucleic  acid based guanidinium compounds

Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.

Biodegradable cationic polymers

Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.

Drug carriers

Polymers comprising a polyethylenimine having a molecular weight less than 600 Daltons, a biodegradable group, and a relatively hydrophobic group that are useful for the delivery of bioactive agents to cells.

Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport of a polymer backbone across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The polymer backbone may include peptide nucleic acid monomer units.

Peptide nucleic acid based guanidinium compounds

The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention comprise (a) providing an organic phase comprising an olefin monomer, a cross-linker, a functionalizing reagent and an initiator; and (b) contacting the organic phase with an aqueous phase under conditions of time and temperature effective to form the polymeric bead.

Polymeric beads for oligomer synthesis

Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.

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Vista, CA, United States of America

Gang Zhao