Fudan University

Iview Therapeutics, Inc.

Comprehensive Drug Enterprises Ltd.

Gang Wei

Chang Liu

Xin Gao

Weiyue Lu

Kuan Jiang

Lingyu Tai

John J Baldwin

Bo Liang

Wenjian Zhang

Johnson Yiu-Nam Lau

Benjamin Tak Kwong Lee

Shun Chiu Dennis Lam

The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.

Polypeptide-based ocular absorption enhancer and application thereof

The present invention provides aqueous formulations containing an anti-infection agent, a biocompatible polysaccharide, an osmotic pressure regulator, a pH regulator, and water, wherein a gel containing the therapeutic agent is formed in situ upon instillation of the formulations onto the skin and a body cavity of a subject. The formulations of this invention are useful for treating infectious diseases of skin or a body cavity (e.g., eye, nose, or vagina) of a subject.

Pharmaceutical formulations that form gel in situ

Polypeptide eye absorption enhancer and use thereof

Growing community of inventors

Shanghai, China

Gang Wei