China University of Mining and Technology

University of Science and Technology Beijing

Beijing Gk Laser Technology Co., Ltd.

Wang, Huashan

Niu, Gang

Gang Niu

Bin Xu

Ning Liu

Yong Wang

Xuejun Sun

Fei Ma

Liyun Yang

Renshu Yang

Zhongwei Fan

Xinmin Ma

Qunshan Yang

Liang Ma

Chaoyang Sun

Bingyu Liu

Donghui Man

Siyuan Huang

Huaquan Zhang

Weiqiang Chen

Huanran Tan

Qingping Chai

Zhidong Guo

Yongping Shao

Jinjun Liao

Huidong Xu

Man Yao

Zhengbai Chen

Hechao Zhu

Yunfeng Ma

Yiqiang Kang

An siRNA specifically binding to M2 macrophage CD206 is provided, which is at least one of siRNA-1, siRNA-2, and siRNA-3, or at least one of siRNA-4, siRNA-5, and siRNA-6. The siRNA specifically combined with CD206 of the M2 macrophage reduces the expression of CD206 by specifically binding to CD206 of the macrophage, thereby promoting the proliferation of the M2 macrophage and further inhibiting the proliferation and migration of tumor cells.

siRNA specifically binding to M2 macrophage CD206 and application thereof

Disclosed is a full-face shaft boring machine, a boring system and a boring method. The full-face shaft boring machine includes a cutterhead structure provided with an outer tapered surface structure protruding in a boring direction. The outer tapered surface structure surrounds an outer circumferential side of the rotation center of the cutterhead structure, and a radial cross section of the outer tapered surface structure gradually decreases in the boring direction; at least one receiving port for rock slag to pass through is formed at the taper top of the outer tapered surface structure and runs through the cutterhead structure in the boring direction; and a slag discharging assembly for discharging the rock slag is arranged on a side of the cutterhead structure away from the boring direction.

Full-face shaft boring machine, boring system, and boring method

A passively mode-locked picosecond laser device comprising a pump source, a laser crystal, a laser cavity, a mode-locked output structure is provided. In the device, the pump source is placed at the side of the incident end surface of the laser crystal; the laser cavity includes a plane reflective mirror and a first plano-concave mirror, the reflective mirror is placed opposite to the concave surface of the plano-concave mirror and located on the position of the focal radius of the plano-concave mirror. The normal direction of the reflective mirror and the axis of the plano-concave mirror form a small angle therebetween; the laser generated from the laser crystal oscillates in the laser cavity, and output through the mode-locked output structure. The device uses a stable cavity design of the equivalent confocal cavity, which can increase the optical path, reduce the repetition frequency, and significantly reduce the cavity length and volume.

Passively mode-locked picosecond laser device

Growing community of inventors

Beijing, China

Gang Niu