Millennium Pharmaceuticals Limited

Halliburton Energy Services, Inc.

Takeda Pharmaceutical Company Limited

Gang Li

Tricia J Vos

Francois Soucy

Courtney A Cullis

Indu T Bharathan

Yongbo Hu

Stephen G Stroud

Paul E Fleming

He Xu

Kenneth M Gigstad

Jeffrey P Ciavarri

Yingchun Ye

Michael D Sintchak

Mario Girard

Chris Blackburn

Krista E Gipson

Mansoureh Rezaei

Jianping Guo

Jouhara Chouitar

Natalie D'Amore

Janice Lee

Shomir Ghosh

Dominic J Reynolds

Tracy J Jenkins

Bing Guan

Amy M Elder

Tzu-Tshin Wong

Matthew O Duffey

Tianlin Xu

Mingshi Dai

Douglas F Burdi

Charles A Minor

Robert A Bennett

Daniel David Gleitman

Steven P Langston

Stepan Vyskocil

Hirotake Mizutani

Alexandra E Gould

Paul D Greenspan

Dylan Bradley England

Syed Muhammad Farrukh Hamza

Jeffrey Ciavarri

Masaaki Hirose

David B Allison

Jesse Clay Hampton

Masanori Okaniwa

Kenneth E Williams

Dandan Hu

Andrew John Eis

Costas Christofi

Ahmed Kenawi

Krista E Granger

Miho Mizutani

Kenneth Edward Williams

The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases. The present disclosure relates to a compound represented by the Formula (I):

Sting modulator compounds, and methods of making and using

The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases. The present disclosure relates to a compound represented by the Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof. 

A method of testing mechanical properties of an earth formation can include disposing a probe in a wellbore, impacting the probe against a wall of the wellbore, and measuring a parameter related to at least one of a displacement, displacement rate, strain, and strain rate, of at least one of the probe and the formation. Another method can include disposing a probe and a known material in a wellbore, and after the disposing, penetrating the known material with the probe. Another method can include disposing a probe in a wellbore, measuring a displacement of the probe into a wall of the wellbore while measuring a load applied to the probe, and applying fluid pressure to the formation via the probe.

In-situ geomechanical testing

The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R, R, R, R, R, L, L, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Heteroaryls and uses thereof

The present invention provides a compound of formula I: 

In some aspects, an acoustic analysis system includes an acoustic source and a laser vibrometer. In some instances, the acoustic source can generate an acoustic signal in a wellbore defined in a subterranean region, and the laser vibrometer can detect movement of a surface in the wellbore in response to the acoustic signal. The detected movement can be analyzed, for example, to identify properties of materials in the subterranean region.

Analyzing subsurface material properties using a laser vibrometer

The present disclosure relates to identifying potential fracture treatment locations in a rock formation for oil and/or gas production based on production potential. One example method includes receiving internal imaging data of a core sample of a rock formation; generating a digital core sample model of the structure of the core sample based on the internal imaging data; analyzing the core sample model to determine the density distribution of a deposit in the core sample; and determining a production potential value from the density distribution of the deposit.

Identifying potential fracture treatment locations in a formation based on production potential

Methods for acquiring, cataloguing, and analyzing digital core samples taken of subterranean formations are disclosed. One embodiment provides a method that includes obtaining an image or a series of images of at least a portion of a subterranean formation; simulating, by a computing device, a fracturing characteristic of the subterranean formation based on the image or the series of images; and cataloguing the image or the series of images in a formation fingerprinting database.

Optimizing subterranean treatment characteristic by digital geoinformatics

A method and apparatus for determining a stress field in a subterranean formation include deploying a stress measurement tool on a tubular string, opening at least three fractures in three different radial directions in the subterranean formation, and closing the at least three fractures. The at least three fractures are reopened while measuring stress and strain conditions. From the reopening, a tangential stress component for each of the at least three fractures is determined. From the tangential stress components and radial directions of the at least three fractures, the stress field of the subterranean formation is determined.

Apparatus and measuring stress in a subterranean formation

This invention provides compounds of formula IA or IB: wherein HY, R, R, and G, are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

This invention provides compounds of formula I: 

Thiolactams and uses thereof

Growing community of inventors

Westborough, MA, United States of America

Gang Li