University of Texas System

Gang Huang

Jinming Gao

Xinpeng Ma

Yang Li

Yiguang Wang

Baran D Sumer

Tian Zhao

Zhijian Chen

Qi Wei

Yang-Xin Fu

Zhaohui Wang

Hua Wang

Min Luo

Haocheng Cai

Yuliang Liu

The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

Library of pH responsive polymers and nanoprobes thereof

In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.

Sting activating nanovaccine for immunotherapy

Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R, R, R, R, R, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer. 

Naphthoquinones, pro-drugs, and methods of use thereof

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Plano, TX, United States of America

Gang Huang