University of Massachusetts

University of Masachusetts

Gang Han

Jie Shen

Ling Huang

Yang Zhao

Jing Peng

Zhanjun Li

Tian Xue

The invention provides a novel class of long-acting photoreceptor-binding nanoparticles, methods of their preparation, and compositions and uses thereof. The invention also relates to use of such nanoparticles and compositions for NIR light sensation and pattern vision, visual enhancement and repair, and other ophthalmology therapies.

Long-acting photoreceptor-binding nanoparticles, and compositions and methods thereof

The invention provides a novel class of MRI contrast agents based on biogenic hemin and compositions and methods of preparation and use thereof.

Biogenic hemin-based MRI contrast agents, and compositions and methods thereof

The invention provides a novel class of materials that possess triplet-triplet annihilation upconversion, compositions and methods of preparation and use thereof. The invention also relates to use of such materials and nanoparticles, for example, in stimulus-responsive, in situ delivery of biologically active agents.

Triplet-triplet annihilation upconversion system, and compositions and methods thereof for drug delivery

The invention provides a novel class of clearable, tumor-targeting and human protein-based MRI nanoprobes and contrast agents and their compositions, and methods of preparation and use thereof.

Tumor-targeting, clearable human protein-based MRI nanoprobes, and compositions and methods thereof

This invention provides a groundbreaking approach to PLNPs and their preparation. In particular, the synthetic methodology disclosed herein fundamentally differs from the traditional solid-state annealing reactions that require extreme and harsh reaction conditions. In one unique aspect of the invention, a simple, one-step mesoporous template method utilizing mesoporous silica nanoparticles (MSNs) is disclosed that affords in vivo rechargeable NIR-emitting mesoporous PLNPs with uniform size and morphology. In another unique aspect of the invention, the novel synthetic approach is based on aqueous-phase chemical reactions conducted in mild conditions, resulting in uniform and homogeneous PLNPs with desired size control (e.g., sub-10 nm).

Homogeneous persistent luminescence nanocrystals and methods of preparation and application thereof

The invention provides a novel class of NIR-absorbing biocompatible organic nanoparticles for effective imaging, targeting and treatment of deep-tissue cancers or tumors. The invention enables a new platform for precise cancer- or tumor-targeting theranostics and clinical cancer treatment.

Ultralow-power near infrared lamp light operable targeted organic nanoparticle photodynamic therapy

The invention generally relates to materials and methods for creating and/or utilizing upconverting luminescence. More particularly, the invention relates to novel compositions (e.g., nanoparticles) and related methods of preparation and use that enable upconverting luminescence with an efficient excitation optimized at about 800 nm. A unique class of cascade sensitized tri-doped UCNPs with a biocompatiable 800 nm excitable property are disclosed herein, for example, tri-doped &#x3b2;-NaYF:Nd, Yb, Er (Tm)/NaYFUCNPs, which employ Ndas 800 nm photon sensitizer and Ybas bridging ions, having strong green or blue upconversion emissions without photobleaching.

Compositions and methods for upconverting luminescence with engineered excitation and applications thereof

The invention generally relates to materials and methods for creating and/or utilizing upconverting luminescence. More particularly, the invention relates to novel compositions (e.g., nanoparticles) and related methods of preparation and use that enable upconverting luminescence with an efficient excitation optimized at about 800 nm. A unique class of cascade sensitized tri-doped UCNPs with a biocompatible 800 nm excitable property are disclosed herein, for example, tri-doped &#x3b2;-NaYF:Nd,Yb,Er(Tm)/NaYFUCNPs, which employ Ndas 800 nm photon sensitizer and Ybas bridging ions, having strong green or blue upconversion emissions without photobleaching.

The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising &#x3b1;-Na LnLnLnF) and an epitaxial shell (e.g., formed from CaF; wherein Lnis Yb), and related methods of preparation and uses thereof.

Coated up-conversion nanoparticles

The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising &#x3b1;-Na Ln, LnLnF) and an epitaxial shell (e.g., formed from CaF; wherein Lnis Yb), and related methods of preparation and uses thereof.

Growing community of inventors

Shrewsbury, MA, United States of America

Gang Han