Lupin, Inc.

Ganesh Kakade

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Milind Dattatraya Sindkhedkar

Manojkumar Ramprasad Shukla

Prathap Sreedharan Nair

Samiron Phukan

Nilesh Raghunath Khedkar

Sachin Sethi

Pradeep Rangrao Patil

Dagadu Dube

Vikas Sitaram Tambe

Pradip Balu Wagh

Sudhakar Maruti Balgude

Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, Rto R, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

Substituted tricyclic compounds

Growing community of inventors

Pune, India

Ganesh Kakade