Egis Gyogyszergyar Rt.

G&eacute;za Szab&oacute;

Gyula Simig

K&aacute;roly Tihanyi

J&oacute;zsef Bark&oacute;czy

Andr&aacute;s Egyed

L&aacute;szl&oacute; Bal&aacute;zs

Imre Dom&aacute;n

Zolt&aacute;n Greff

Zolt&aacute;n R&aacute;tkai

G&eacute;za Schneider

Tam&aacute;s Szabados

Istv&auml;n Gacs&aacute;lyi

Mikl&oacute;s V&eacute;gh

Annam&aacute;ria Sim&oacute;

G&aacute;bor Gigler

Judit Cseleny&aacute;k

Istv&aacute;n Gyerty&aacute;n

P&eacute;ter K&oacute;tay Nagy

P&eacute;ter Seres

Attila Kov&aacute;cs

Gy&ouml;rgy L&aacute;vay

The disclosure relates to a novel 8-substituted-9H-1,3-dioxolo-&lsqb;4,5-h&rsqb;&lsqb;2,3&rsqb;benzodiazepine compound of formula I and pharmaceutically acceptable quaternary ammonium salts thereof, a process for preparing the same, a pharmaceutical composition containing a 8-substituted-9H-1,3-dioxolo-&lsqb;4,5-h&rsqb;&lsqb;2,3&rsqb;benzodiazepine compound, and a method of treatment using the pharmaceutical composition. A complete description of the compound of formula I is found in the specification. The compounds of the general formula I possess unique competitive AMPA/kainite antagonist properties making them useful in the treatment of diseases where inhibition of the AMPA/kainite receptors may a favorable effect.

8-substituted-9H-1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives, as AMPA/kainate receptor inhibitors

Growing community of inventors

Budapest, Hungary

Géza Szabó

Growing community of inventors

Budapest, Hungary

G&eacute;za Szab&oacute;

Géza Szabó