Gilead Pharmasset LLC

Arbutus Biopharma Corporation

Gilead Sciences, Inc.

Ganapati Reddy Pamulapati

Michael Joseph Sofia

Bruce Ross

Hai-Ren Zhang

Suguna Rachakonda

Byoung-Kwon Chun

Peiyuan Wang

Bruce S Ross

Dhanapalan Nagarathnam

Jinfa Du

Keshab Sarma

Scott Alan Wolckenhauer

Lars V Heumann

Martin Gerald Teresk

Benjamin James Roberts

Shinji Fujimori

Kevin McCormack Allan

Xiang Wang

Wonsuk Chang

Christopher M Levins

Katie Ann Keaton

Katie Ann Brown

Grace May Huynh

Grace May

Bruce D Dorsey

Dimitar B Gotchev

Duyan Nguyen

Shuai Chen

Kevin M Allan

Chrisopher M Levins

Dhanpalan Nagarathnam

Devan Naduthambi

Mahesh Kumar Pallerla

The present disclosure relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.

Methods for preparing substituted pyridinone-containing tricyclic compounds

The present disclosure provides processes for the preparation of a compound of formula: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates.

Processes for preparing antiviral compounds

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.

Nucleoside phosphoramidates

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.

A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.

Synthesis of purine nucleosides

Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing the same.

Stereoselective synthesis of phosphorus containing actives

Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof, represented by the following structure: 

Nucleoside cyclicphosphates

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Plainsboro, NJ, United States of America

Ganapati Reddy Pamulapati