Akeso Biopharma, Inc.

Taizhou Hanzhong Biopharmaceutics, Inc.

Hanx Biopharmaceutics, Inc

Gan Xi

Ying Huang

Faming Zhang

Baiyong Li

Yu Xia

Zhongmin Maxwell Wang

The present invention provides a recombinant protein. The recombinant protein includes an anti-PD-1 antibody and human SIRPA extracellular domain. The N-terminus of the human SIRPA extracellular domain is linked to the C-terminus of the heavy chain of the anti-PD-1 antibody.

Anti-PD-1/CD47 bispecific antibody and application thereof

Proposed is an anti-PD-1 monoclonal antibody or an antigen binding fragment thereof, comprising a heavy chain variable region having at least one of the amino acid sequences listed below: (1) the amino acid sequence shown in SEQ ID NO: 1; (2) the amino acid sequence shown in SEQ ID NO: 3; (3) the amino acid sequence shown in SEQ ID NO: 5; and (4) an amino acid sequence having more than one conservative amino acid mutation compared with (1)-(3).

Anti-PD-1 monoclonal antibody

Provided is a monoclonal antibody against programmed death-1 (PD-1) or applications thereof, where the monoclonal antibody against PD-1 comprises a neonatal Fc Receptor (FcRn)-binding site having an amino acid sequence of SEQ ID NO: 5.

Monoclonal antibody against PD-1 and application thereof

Growing community of inventors

Hubei, China

Gan Xi