Research Development Foundation

Other

David T. Bailey

Joseph J. Hoffmann

Jordan U. Gutterman

Mary Blake Tracey

Charles J. Arntzen

Gamini S. Jayatilake

Vanas Oncology

Gamini S Jayatilake

Charles Joel Arntzen

David T Bailey

Jordan U Gutterman

Mary E Blake

Joseph J Hoffmann

Xiong Fu

Ajit Bharti

Daniel Prabakaran

Vipul C Chitalia

Charles J Arntzen

This invention relates to the use of plant extracts, compositions thereof, and compounds isolated from plant extracts or obtained from synthetic means thereof, for the treatment of diseases, disorders or symptoms thereof (e.g., proliferation disorders, cancer).

Compositions and methods of use

The invention provides saponin mixtures and compounds which are isolated from the speciesand methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

Triterpene compositions and methods for use thereof

The invention provides novel saponin mixtures and compounds which are isolated from the species and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

Growing community of inventors

Broomfield, CO, United States of America

Gamini S Jayatilake