Hadasit Medical Research Services and Development Ltd.

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Galith Abourbeh

Eyal Yosef Mishani

Alexander Levitzki

Haim D Danenberg

Samar Dissoki

Hana Billauer

Nanette Freedman

Ohad Ilovich

Sharon Dotan

Moshe Bocher

Provided is radiolabeled ammonium salts and uses thereof as myocardial perfusion agents in molecular imaging.

Molecular imaging agents

Novel epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors, pharmaceutical compositions including same and their use in the treatment of EGFR-TK related diseases or disorders are disclosed. Novel radiolabeled EGFR-TK inhibitors as their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are further disclosed. The disclosed EGFR-TK inhibitors comprise a polyalkylene glycol moiety and/or a hydroxy-containing moiety and are characterized by improved solubility, biostability and bioavailability. Processes of preparing the disclosed EGFR-TK inhibitors and of radiolabeling same, via, for example, one-step radiosyntheses, are also disclosed.

Polyalkylene glycol derivatives of inhibitors of epidermal growth factor receptor tyrosine kinase

Growing community of inventors

Jerusalem, Israel

Galith Abourbeh