Wyeth

American Home Products Corporation

Galina Vid

Silvio Iera

Panolil C Raveendranath

Zhixian Ding

Warren Chew

Timothy Thomas Curran

John Hamilton Sellstedt

John R Potoski

Gregg Brian Feigelson

Sreenivasulu Megati

Joseph Zeldis

Jianxin Ren

Anita W Chan

Arthur G Mohan

John Potoski

Bogdan Kazimierz Wilk

James C Keith, Jr

Heather Anne Harris

Anita Wai-Yin Chan

Leo M Albert

Christopher P Miller

John Leo Considine

Weiguo Liu

Xinxu Shi

Greg Feigelson

John Richard Potoski

The present invention concerns processes for the production and purification of compounds of the formula: where R-Rare as defined in the specification. Preferred processes of the invention utilize a lithium bis(trimethylsilyl)amide, lithium dicyclohexylamide, or potassium bis(trimethylsilyl)amide base and a R&#x2014;X alkylating agent where X is as described in the specification. An alcohol preferably is added to the product solution is used to promote crystallization of the desired product.

Preparation and purification of 4-(indazol-3-yl)phenols

This invention relates to a process for the preparation of 6-hydroxyequilenins, which are useful as estrogenic agents.

Preparation of 6-hydroxyequilenins

Methods of preparing compounds of Formula I are provided.

Process for the synthesis of derivatives of halo-[2,3-F] quinoline

The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid, and esters thereof.

Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid and esters thereof

This invention provides estrogen receptor modulators of formula I, having the structure wherein, 

6-Hydroxyequilenins as estrogenic agents

Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline

Methods of preparing compounds of Formula Iare provided.

Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline

Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino- &lsqb;2,3-f&rsqb; quinoline

The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula:

Aryloxy-alkyl-dialkylamines

The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are, independently, selected from H; C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently selected from H, halogen, --NO.sub.2, alkyl, alkoxy, C.sub.1 -C.sub.6 perfluorinated alkyl, OH or the C.sub.1 -C.sub.4 esters or alkyl ethers thereof, --CN, --O--R.sup.1, --O--Ar, --S--R.sup.1, --S--Ar, --SO--R.sup.1, --SO--Ar, --SO.sub.2 --R.sup.1, --SO.sub.2 --Ar, --CO--R.sup.1, --CO--Ar, --CO.sub.2 --R.sup.1, or --CO.sub.2 --Ar; and Y is selected from a) the moiety: ##STR2## wherein R.sub.7 and R.sub.8 are independently selected from the group of H, C.sub.1 -C.sub.6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of --O--, --NH--, --N(C.sub.1 C.sub.4 alkyl)--, --N.dbd., and --S(O).sub.n --.

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New City, NY, United States of America

Galina Vid