Biosense Webster (Israel) Ltd.

Biosense Webster, Inc.

Rutgers, the State University of New Jersey

Siemens Aktiengesellschaft

Krimsky, William Sanford

Monir, George

Kimura, Takehiro

Shalgi, Avi

Waldstreicher, Jonathan Reuben

Bar-Tal, Meir

Hayam, Gal

Schwartz, Yitzhack

Itah, Refael

Amit, Matityahu

Gal Hayam

Tal Haim Bar-on

Ziyad Zeidan

Meir Bar-Tal

Aharon Turgeman

Shiran Eliyahu

Refael Itah

Roy Urman

Yaniv Ben Zrihem

Stanislav Goldberg

Michael Maydel

Michael Timofeyev

Yariv Avraham Amos

Natan Sharon Katz

Richard P M Houben

Lior Botzer

Assaf Preiss

Alaa Zoubi

Yoram Chmiel

Norbert Rahn

Frank Sauer

Kristine B Fuimaono

Chenyang Xu

Reinmar Killmann

Yitzhack Schwartz

William Sanford Krimsky

Shmuel Auerbach

Assaf Cohen

Robert D Ainsworth

Eliyahu Ravuna

Elad Nakar

Stuart Williams

Morris Ziv-Ari

Hiroshi Nakagawa

Jonathan Reuben Waldstreicher

Tsahi Grinberg

Matityahu Amit

Itai Doron

Avi Shalgi

Alon Baram

Atul Verma

Wagdi Hani Hagla

Nakdimon Nissim Levy

Milad Abbas El Haddad

Amardeep Saluja

Yuval Karmi

Richard Petrus Maria Houben

Yaron Kadoshi

Yoav Benaroya

Richard P Houben

Mattias Francis Duytschaever

Takehiro Kimura

George Monir

Ana Kaufman

Jaron Breitman

Tal Haim Baron

Inbal Dubiner

Limor Elran

Hen Kdoshai Scliar

Einat Shapira

Daniel Melby

Nuno Miguel Rocha Cortez-Diaz

Eva Ishay

Valery Trofimov

Warren Jackman

Yaariv Khaykin

William Sanford Krimskiy

Houben Richard PM

Meir Bae-Tal

Amardeep S Saluja

Tal Haim Bar-On

Richard PM Houben

Rafael Itah

A medical tool testing apparatus comprising a vessel. The vessel comprises a scaffold formed from biomaterial, live cardiac tissue, generated from cardiac cells, proliferating on the scaffold, the live cardiac tissue configured to generate electrical activity. The vessel also comprises a medical tool, in contact with live cardiac tissue, used for a medical procedure within patient anatomy. Operational features of the medical tool are determined by a visually perceptible condition of the live cardiac tissue.

Apparatus for testing a cardiac catheter utilizing live cardiac cells

A method is described herein. The method is implemented by an optimization engine executed by a processor. The optimization engine receives data that includes performance metrics of mapping and ablation procedures. In turn, the optimization generates procedure expected outcomes for the mapping and ablation procedures based on the data and success predictions for a current ablation procedure utilizing the procedure expected outcomes. The optimization engine, also, outputs an ablation recommendation based on the success predictions.

Identification of ablation gaps

Intracardiac electrograms are recorded using a multi-electrode catheter and respective annotations established. Within a time window a pattern comprising a monotonically increasing local activation time sequence from a set of electrograms from neighboring electrodes is detected. The set is reordered and displayed for the operator.

Identification and visualization of cardiac activation sequence in multi-channel recordings

A method for evaluation of electrical propagation in the heart includes receiving a pacing signal applied to a heart of a patient, the pacing signal including a sequence of normal and shorter, abnormal, pacing stimuli. A responsive cardiac signal is received, that is sensed by electrodes at a location in the heart and on the body surface of the patient. A model response is found and annotated from evoked potentials caused by the normal pacing stimuli. A correlation is made between the model response along the different signal sections to find and calculate a normal and decremental time delays between the pacing stimuli and respectively resulting evoked potentials at a tissue location. A time difference is calculated, between the normal time delay and the decremental time delay. An EP map of at least a portion of the heart is presented to a user, with a graphical indication of the time difference presented at the tissue location.

Annotation of slow electrophysiological (EP) cardiac paths related to ventricular tachycardia (VT)

A probe generates location signals, and has an electrode at a distal end that acquires from heart chamber surface positions electrical signals due to a conduction wave traversing the surface. A processor derives LATs from the electrical signals, calculates a first time difference between LATs at a first pair of positions and a second time difference between LATs at a second pair of positions. The processor calculates first and second LAT-derived distances as products of the first and second time differences with a conduction wave velocity, identifies an arrhythmia origin at a surface location where a first difference in distances from the location to the first pair of the positions is equal to the first LAT-derived distance, and a second difference in distances from the location to the second pair of the positions is equal to the second LAT-derived distance, and marks the origin on a surface representation.

Finding the origin of an arrythmia

Methods, apparatus, and systems for medical procedures are disclosed herein and include sensing a plurality of tissue electrical potentials at an organ area of an organ, by one or more electrodes on a catheter, determining a number of peak electrical potentials from the plurality of first tissue electrical potentials such that the a peak electrical potential exceeds a potential threshold, determining a first visual characteristic based on the number of peak electrical potential and displaying a rendering of the organ comprising the organ area such that the rendering of the first organ area comprises the first visual characteristic.

Enhanced visualization of organ electrical activity

A catheter may be adapted to map a chamber of the heart. The catheter may include a magnetic and/or ultrasound sensor for navigation. The body of the catheter may be pliable and configured to form a predetermined shape upon exiting a catheter sheath. Upon exiting the catheter sheath, the catheter body may be configured to form one or more loops, and the loops may be non-overlapping loops. In some examples, the non-overlapping loops may be concentric loops. Alternatively, the catheter body may be configured to form one or more splines. The catheter body may include an embedded electrode assembly. The electrodes of the electrode assembly may be may be arranged in one or more rows and configured to detect a wave front. The electrode assembly may also be configured to generate and activation sequence and determine a direction of an activation source. The electrode assembly may also be configured to determine the type of activation source, for example a rotational activation source, a focal activation source, and a single-wide activation source.

Non-overlapping loop-type or spline-type catheter to determine activation source direction and activation source type

A system and method of identifying focal sources is presented. The method can comprise detecting, via sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the sensors having a location in a heart and indicating electrical activity of the heart, each signal comprising at least an R wave and an S wave; creating an R-S map comprising an R-to-S ratio for each of the ECG signals, the R-to-S ratio comprising a ratio of absolute magnitude of the R wave to absolute magnitude of the S wave; identifying, for each of the ECG signals, local activation times (LATs); and correlating the R-to-S ratios for the ECG signals on the R-S map and the identified LATs and using the correlation to identify the focal sources.

Region of interest focal source detection using comparisons of R-S wave magnitudes and LATs of RS complexes

A medical display processing device and a method of reusing data includes acquiring, over time via electrodes, electrical signals each acquired via one of the electrodes and indicating electrical activity at a location of a portion of patient anatomy in a 3D space. Electrical signal data, corresponding to the electrical signals, is filtered according to first filter parameter settings and first mapping information is generated for displaying a map of the portion of patient anatomy and the filtered electrical signal data. An indication of a region of the portion of patient anatomy on the map is received and second mapping information is generated for displaying, at the region on the map, a portion of the electrical signal data previously filtered from display.

Data reuse for filling in missing data points

A method includes receiving a bipolar signal sensed by a pair of electrodes at a location in a heart of a patient. One or more electrocardiogram (ECG) signals are received, sensed by body-surface electrodes attached to the patient. Two or more successive QRS complexes are identified in the bipolar signal. One or more activations are detected in the bipolar signal, which occur within a window-of-interest that begins at least a given time with respect to the identified QRS complexes. The detected activations are checked whether they are late potentials, by verifying whether (i) the activations do not coincide with a predefined event observed in the ECG signals, and (ii) the activations are repeatable in the successive QRS complexes. In response to deciding that at least one of the detected activations is a late potential, the latest of the at least one of the late potentials is visualized to a user.

Annotation of late potentials comprising local abnormal ventricular activation (LAVA) signals

Methods, apparatus, and systems are provided for facilitating the navigation of a catheter between first and second locations within a subject based on display of serial images corresponding to positions of the catheter at successive incremental times. Image production includes sensing catheter positions to produce location data for each time increment. For each position P, the corresponding location data is processed to respectively produce an image Ireflecting the position of the catheter at a time T. Each image Iis successively displayed at a time equal to T+d, where d is an image processing visualization delay. Upon a condition that the catheter is displaced to a selected interim location between the first and second locations, the processing of the location data is switched from being performed by a first process associated with a first visualization delay to a second process associated with a second different visualization delay.

Enhanced catheter navigation methods and apparatus

A probe generates location signals, and has an electrode at a distal end which acquires from heart chamber surface positions electrical signals due to a conduction wave traversing the surface. A processor derives LATs from the electrical signals, calculates a first time difference between LATs at a first pair of positions and a second time difference between LATs at a second pair of positions. The processor calculates first and second LAT-derived distances as products of the first and second time differences with a conduction wave velocity, identifies an arrhythmia origin at a surface location where a first difference in distances from the location to the first pair of the positions is equal to the first LAT-derived distance, and a second difference in distances from the location to the second pair of the positions is equal to the second LAT-derived distance, and marks the origin on a surface representation.

A method for cardiac treatment, which includes acquiring and saving an initial map of a chamber of a heart of a patient in an initial ablation procedure, with locations of ablation lesions marked on the initial map. In preparation for a redo ablation procedure, subsequent to the initial ablation procedure, a current map of the chamber is acquired, the initial map is registered with the current map, and the locations of the ablation lesions from the registered initial map are marked and displayed on the current map.

Enhancing efficiency of repeat ablation by merging current and previous maps

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