Sony Corporation

Sony Group Corporation

Gakuji Hashimoto

Tatsumi Ito

Kenji Yamamoto

Takeshi Yamasaki

Masataka Shinoda

Shoji Akiyama

Yuji Akiyama

Masaya Kakuta

Hiroto Kasai

Junji Kajihara

Shunpei Suzuki

Shingo Imanishi

Hirokazu Tatsuta

Suguru Dowaki

Tetsuro Kuwayama

Hironobu Tanase

Takayuki Kato

Toshio Watanabe

Kazuya Takahashi

Atsushi Iida

Hideo Sato

Koichiro Kishima

Takashi Nakao

Isao Ichimura

Akira Kouchiyama

Kengo Hayasaka

Yasunobu Kato

Yosuke Muraki

Motohiro Furuki

Kiyoshi Osato

Akiko Tsuji

Kouhei Hatamoto

Hirotaka Yoshida

Kenji Sugawara

A microscope device includes an opening () that includes a first slit and a second slit through which a plurality of pieces of light from an observation target resulting from a plurality of pieces of irradiation light emitted to the observation target and having different wavelengths pass, a dispersion element that wavelength-disperses the plurality of pieces of light passing through the opening (), and an imaging element () that receives the plurality of pieces of light wavelength-dispersed by the dispersion element. The imaging element () performs light reception so that, as for the plurality of pieces of light wavelength-dispersed, zeroth-order light of light passing through the second slit and first-order light of light passing through the first slit do not overlap with each other.

Microscope device, spectroscope, and microscope system

Provided is a technology for preparing a mixture including multiple types of microparticles in accordance with a predetermined ratio. The present technology provides a microparticle sorting device () including a control unit () comprising a determination unit that determines whether microparticles are sorted, on the basis of light generated by irradiating, with light, the microparticles flowing through a flow channel (), in which the determination unit performs a primary sorting determination to determine, on the basis of characteristics of the light generated, whether the microparticles belong to any one of two or more different microparticle populations, and then performs a secondary sorting determination to determine whether the microparticles determined to belong to any one of the microparticle populations in the primary sorting determination are sorted, on the basis of the particle constituent ratio specified for the two or more different microparticle populations. This technology may be used to prepare a cell therapeutic agent comprising a mixture of cells of different types in a predefined ratio, e.g. a mixture of various types of CAR T-cells showing a synergistic anti-tumor activity.

Microparticle sorting device, cell therapeutic agent manufacturing device, microparticle sorting method and program

The present technology is to provide a technique for further optimizing microparticle suction conditions, using a microparticle sorting microchip. The present technology provides a method for optimizing microparticle suction conditions, using a microparticle sorting microchip including: a main flow channel in which a sheath solution and a microparticle-containing sample solution flow; and a pressure chamber that sucks microparticles. The method includes: the step of acquiring data of a velocity V of each microparticle, by introducing the sheath solution and the microparticle-containing sample solution into the main flow channel, and detecting the point of time at which the microparticle passes through a predetermined position in the main flow channel; and the step of controlling the pressure for sucking the microparticles, on the basis of the data of the velocity V of each microparticle.

Method for optimizing microparticle suction conditions, microparticle sorting device, microparticle sorting system, and microparticle sorting program

A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.

Fluorescence observation apparatus and fluorescence observation method

To provide a technology of optimizing a suction condition of a microparticle. The present technology provides

Optimizing method of suction condition of microparticle and microparticle fractionating device

Micro flow channel chip

In the present technology, the timing at which suction is performed is optimized in order to enhance the microparticle separation performance in a technology for separating target microparticles in a microchip. For this purpose, the present technology provides a method of optimizing a microparticle suction condition, and the like, using a microchip having a main flow channel through which a liquid containing a microparticle flows, a microparticle suction flow channel arranged coaxially with the main flow channel, and a branch flow channel branching from the main flow channel. The method includes: a branch point specifying process of specifying a branch point at which the branch flow channel branches from the main flow channel; and a time assignment process of assigning a time Tto be applied to suction of the microparticle.

Method of optimizing microparticle suction condition and microparticle separation device

A sample feeding apparatus includes a first cylinder, a second cylinder, and a sealing section. The first cylinder is configured to be mounted with a sample tube. The second cylinder is configured to move the first cylinder between a first position and a second position, the first position being for mounting of the sample tube, the second position being for feeding of a sample in the sample tube. The sealing section is configured to cover the sample tube, the sample tube being mounted to the first cylinder being at the second position, the first cylinder applying pressure to an inner space of the sealing section at the second position.

Sample feeding apparatus, flow cytometer, and sample feeding method

Disclosed herein is an optical measuring device including: a light applying section configured to apply exciting light to a sample flowing in a channel; and a scattered light detecting section configured to detect scattered light generated from the sample irradiated with the exciting light on the downstream side of the sample in the traveling direction of the exciting light; the scattered light detecting section including a scattered light separating mask for separating the scattered light into a low numerical aperture component having a numerical aperture not greater than a specific value and a high numerical aperture component having a numerical aperture greater than the specific value; a first detector for detecting the low numerical aperture component; and a second detector for detecting the high numerical aperture component.

Optical measuring device and optical measuring method

Micro flow channel chip for a flow cytometer

Growing community of inventors

Kanagawa, Japan

Gakuji Hashimoto