Advanced Tissue Sciences, Inc.

Histogen, Inc.

Marrow-tech, Inc.

Skinmedica, Inc.

Adaptive Biologix, Inc.

Other

Allergan, Inc.

Allergen, Inc.

Theregen, Inc.

Advanced Tissue Sciences, Inc. Formerly Marrow-tech

Gail K Naughton

Brian A Naughton

Jonathan N Mansbridge

Mark Baumgartner

Kyle Nickey

Joan Zeltinger

Emmett Pinney

R Emmett Pinney

Anthony Ratcliffe

Mark A Applegate

Lee K Landeen

Andreas Kern

Frank Ziegler

David L Horwitz

Noushin Dunkelman

Francis C Zeigler

Jane Willoughby

Alvin Edward Peterson

Anthony F Purchio

John F Hansbrough

Frank Zeigler

Ronda Elizabeth Schreiber

Dror Seliktar

Michael Zimber

Robert Emmett Pinney

Stuart K Williams

Robert E Pinney

Robert S Kellar

Michael Siani-Rose

The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.

Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions

The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.

Extracellular matrix compositions for the treatment of cancer or immunological diseases

Extracellular matrix compositions for the treatment of cancer

Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions for methods of treating tissue injury

Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, or formulated with a salve or ointment for topical applications. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.

Conditioned cell culture medium compositions and methods of use

The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible three-dimensional surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.

Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells

Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions

Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro

Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.

Growing community of inventors

Del Mar, CA, United States of America

Gail K Naughton