Baylor College of Medicine

Immatics Us, Inc.

Gagan Bajwa

Malcolm K Brenner

Melinda Mata

Mamta Kalra

Caroline Eva Arber Barth

Embodiments of the disclosure include methods and compositions related to improvements of T cell therapy. In particular embodiments, CD8+ T cell therapy is enhanced upon expression of transgenic E08αβ co-receptor in the CD8+ T cells. In certain embodiments, CD4+ T cells are rendered to have cytotoxic cell function for adoptive transfer upon expression of transgenic E08αβ co-receptor in the CD4+ T cells. In specific embodiments, TCR-expressing and E08αβ co-receptor-expressing CD4+ and CD8+ T cells are utilized in adoptive transfer.

Reprogramming CD4 t cells into cytotoxic CD8 cells by forced expression of CD8ab and class 1 restricted t cell receptors

The present disclosure relates to T cells capable of co-expressing T cell receptors ('TCR') together with CD8 polypeptides and the use thereof in adoptive cellular therapy. The present disclosure further provides for modified CD8 sequences, vectors, and associated methods thereof.

Growing community of inventors

Houston, TX, United States of America

Gagan Bajwa