Dac S.r.l.

Gaetano Gargiulo

Saverio Minucci

Antonello Mai

Marco Ballarini

Silvio Massa

Pier Giuseppe Pelicci

Stefania Gagliardi

Florian Thaler

Gilles Pain

Andrea Colombo

New histone deacetylase inhibitors according to the general formula (I) wherein: Q is a bond, CH, CH&#x2014;NRR, NRor oxygen, X is CH or nitrogen, Y is a bond, CH, oxygen or NR, Z is CH or nitrogen, R, Rare, independently, hydrogen, halogen, C-Calkyl or C-Chaloalkyl, R, Rare, independently, hydrogen or C-Calkyl, and R, R, Rand Rare as further defined in the specification.

Class of histone deacetylase inhibitors

New inhibitors of histone deacetylases having antitumor activity, and the process of preparation thereof are herein described. These compounds belong to the structural formula (I) where Ris a linear or branched chain containing at least two conjugated double bonds, A is an optionally substituted phenyl or pyridyl ring, Ar is an aryl or heteroaryl group, and Ris hydrogen or alkoxyalkyl. The application also describes the use of said compounds in the treatment of diseases associated to the deregulation of histone deacetylases activity, such as tumors, as well as the relevant pharmaceutical compositions for administration to patients requiring said treatment.

Histone deacetylases inhibitors

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S. Agnello, Italy

Gaetano Gargiulo