1st Biotherapeutics, Inc.

Gadhe Changdev Gorakshnath

Jinhwa Lee

Jae Eun Kim

Suyeon Jo

Misoon Kim

Keonseung Lim

A Yeong Park

Yeonguk Jeon

Hwajung Nam

Yejin Hwang

Seung Mook Lim

Inyoung Yang

The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salts thereof, a composition comprising the compound, methods of using the compound for the treatment of various disorders associated with HPK1, and methods of preparing these compounds.

Substituted indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors

The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method for treating or preventing an inflammatory and autoimmune diseases, especially neuroinflammation diseases using the compound.

2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds

The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salts thereof, a composition comprising the compound, methods of using the compound for the treatment of various disorders associated with HPK1, and methods of preparing these compounds. 

Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same

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Seoul, South Korea

Gadhe Changdev Gorakshnath