L. Molteni & C. Dei Fratelli Alitti—società Di Esercizio S.p.a.

Molteni Therapeutics S.r.l.

L. Molteni & C. Dei Fratelli Alitti

Other

L. Molteni & C. Dei Fratelli

Molteni L. & C. Dei Fratelli Alitti Societa Di Esercizio S.p.a.

L. Molenti & C. Dei Fratelli Alitti Societa' Di Esercizio Societa' Per

L. Molteni E C. Dei Fratelli Alitti Societa Di Esercizio S.p.a.

L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio Societa' Per Azioni

Gabrio Roncucci

Donata Dei

Giacomo Chiti

Lia Fantetti

Giulio Jori

Daniele Nistri

Annalisa Cocchi

Valentina Paschetta

Maria Paola De Filippis

Francesca Giuntini

Moira Municchi

Francesco Giuliani

Giovanni Neri

Gian Maria Rossolini

Salvatore Demartis

Stefano Mascheroni

Daniela Monti

Silvia Tampucci

Barbara Cosimelli

Ilaria Masini

Marco Possenti

Paolo Sarri

Carmela Alongi

Clara Fabris

Yann Raoul

Aldo Hendrikus Velders

The present invention describes topical formulations for use in photodynamic therapy (PDT) of skin affections, said formulations comprising a Zn-phthalocyanine derivative.

Topical formulations containing phthalocyanine photosensitizers

There is described a phthalocyanine derivative of formula (I) consisting of 4 isomers wherein the relative isomer B content is less than or equal to 1% by weight. 

Phthalocyanine derivative consisting of a mixture of 4 isomers

Self-sterilising products, and in particular novel products comprising phthalocyanine derivatives bound to polymers, a process for the preparation of said products and their use for preparing self-sterilising industrial and medical articles or devices, are described.

Self-sterilizing products

The present invention relates to pharmaceutical compositions comprising metal phthalocyanine analogues of formula (I) and metal chelating compounds having a good bioavailability and enhanced photoinactivation properties against Gram negative bacteria; and to their use for in vivolex vivo applications, such as blood and blood derivatives sterilization. 

Antibacterial compositions comprising metal phthalocyanine analogues

Meso-substituted porphyrins of general formula (I) suitable for the use as photosensitizing agents, in particular in photodynamic therapy, are herein described.

Meso-substituted porphyrins

A process is described for preparing chlorides of phthalocyanine derivatives comprising at least a quaternary ammonium group, products useful as photosensitizing agents in photodynamic therapy.

Process for preparing chlorides of phthalocyanine derivatives comprising at least a quaternary ammonium group

Phthalocyanine derivatives are described having photosensitizing characteristics and high solubility in water, useful for photodynamic treatment of bacterial infections, in particular infections generated by Gram-negative bacteria.

Phthalocyanine derivatives, process for their preparation, pharmaceutical compositions containing them and their use

Meso-substituted porphyrins of general formula (I) suitable for the use as photosensitizing agents, in particular in photodynamic therapy, are herein described. 

The present invention relates to metal-phthalocyanines bearing at least a group containing boron isotopesB orB, covalently bound to the axial positions of metal-phthalocyanine nucleus; moreover it refers to the process for their preparation, the pharmaceutical compositions comprising them and their use for the treatment of neoplastic and dysplastic pathologies in PDT and/or BNCT.

Boronated metal-phthalocyanines, process for their preparation, pharmaceutical compositions comprising them and use thereof

The present invention relates to meta 1-phthalocyanines bearing at least a group containing boron isotopesB orB, covalently bound to the peripheral positions of meta 1-phthalocyanine nucleus; moreover it refers to the processes for their preparation, the pharmaceutical compositions comprising them and their use for the treatment of neoplastic and dysplastic pathologies.

The present invention is directed to metal-phthalocyanines of general formula (I) to the corresponding conjugates, the processes for their preparation and use in the photodynamic therapy of microbial infections (viral, bacterial and mycotic), tumor, pre-cancerous and proliferative pathologies and/or in the diagnosis, as well as for blood and blood derivatives sterilization.

Substituted metal-phthalocyanines, their preparation and the use thereof

The present invention refers to a process for the separation of regioisomeric mixtures of metal phthalocyanines of formula (I), to the regioisomers obtained by this process, and their use as phototherapeutic and photodiagnostic agents 

Separation of regioisomers of metal phthalocyanines

Phthalocyanine analogues having an active group able to link the phthalocyanine t carriers molecules and phthalocyanine to carriers molecules and phthalocyanine analogues as phthalocyanine-carrier conjugates showing enhanced photodynamic properties, red shifted absorption characteristic, all useful for photodynamic therapy, are described. Photosensitizers themselves or the photosensitizers-carriers conjugates are useful compounds either for treatment of various infectious diseases, the in vivo eradication of micro-organisms as well as diseases characterized by cellular hyperproliferation, in particular tumours psoriasis, actinic keratosis, atheromas, endoarterial hyperplasia and prostate hyperplasia. The above compounds can be also useful for blood and blood derivatives sterilization and in vivo/vitro diagnostics.

Metal substituted non-centrosimmetrical phthalocyanine analogues, their preparation and use in photodynamic therapy and in vivo diagnostic

The present invention is directed to metal-phthalocyanines of general formula (I) to the corresponding conjugates, the processes for their preparation and use in the photodynamic therapy of microbial infections (viral, bacterial and mycotic), tumor, pre-cancerous and proliferative pathologies and/or in the diagnosis, as well as for blood and blood derivatives sterilization

The present invention refers to zinc-phthalocyanines of general formula (I) ##STR1## to processes for their preparation and to their use as phototherapeutic and photodiagnostic agents as free molecules and as conjugates with macromolecular carrier molecules.

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Colle Val d'Elsa, Italy

Gabrio Roncucci