Pliva Pharmaceutical and Chemical Works

Sour Pliva

Sour Pliva Farmaceutska, Kemijska Prehrambena I Kozmeticka Industrija,

Pliva Farmaceutska, Kemijska, Prehrambena I Kozmeticka

Gabrijela Kobrehel

Slobodan Djokic

Zrinka Tamburasev

Nevenka Lopotar

Hrvoje Krnjevic

Gorjana Lazarevski

Gordana Radobolja

Olga Carevic

The invention relates to O-methyl derivatives of azithromycin A of the formula (I) ##STR1## wherein Ia R.sup.1 =R.sup.2 =CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 =CH.sub.3, R.sup.4 =R.sup.5 =H

O-methyl derivatives of azithromycin A

10-dihydro-10-deoxo-11-azaerythronolide A compounds and pharmaceutically acceptable acid addition salts of said compounds; methods and intermediates for the manufacture thereof; their use as antiinflammatory agents and processes for their preparation.

10-dihydro-10-deoxo-11-azaerythronolide a compounds, methods and

11-Methyl-11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl-7,13,14-trihydroxy -3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one and derivatives thereof, such as the 13,14-carbonate and C.sub.1 -C.sub.3 -alkanoyl derivatives thereof. The compounds exhibit antibacterial activity.

11-Methyl-11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl-7,1

11-aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof, and process for preparation thereof.

11-Aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof as well

The new antibiotic compounds N-(4-R-benzenesulfonyl)-erythromycylamine, wherein R is a lower alkyl group having 1-5 carbon atoms, an acylamino group wherein the acyl has 2-4 carbon atoms, or a halo group.

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Zagreb, Yugoslavia

Gabrijela Kobrehel