Nerviano Medical Sciences S.r.l.

Farmitalia Carlo Erba

Pharmacia & Upjohn

Pharmacia Italia S.p.a.

Other

Pharmacia & Upjohn Company

Farmitalia Carlo Erba S.r.l. an Italian Body Corporate

Gabriella Traquandi

Paolo Pevarello

Maria Gabriella Brasca

Anna Vulpetti

Sergio Mantegani

Mario Varasi

Paola Vianello

Aldemio Temperilli

Paolo Polucci

Paolo Orsini

Daniele Fancelli

Achille Panzeri

Ron Ferguson

Francesca Quartieri

Roberto D'Alessio

Fulvia Roletto

Chiara Marchionni

Maurizio Pulici

Luigi Bernardi

Patrizia Ferrari

Antonio Longo

Mauro Gobbini

Alessandro Rossi

Alessandra Scolaro

Raffaella Amici

Manuela Villa

Fabio Zuccotto

Patricia Salvati

Tiziano Bandiera

Maria Menichincheri

Italo Beria

Nicola Mongelli

Martha A Warpehoski

Laura Chiodini

Edward L Fritzen

Betsy S Pierce

Marina Caldarelli

Antonella Isacchi

Giovanni Cervi

Alessandra Badari

Claudia Piutti

Stefano Nuvoloni

Michele Modugno

Nicoletta Colombo

Sonia Biondaro

Valeria Pittal&agrave;

Daniel Ruggieri

Ermes Vanotti

Francesco Casuscelli

Enzo Brambilla

Barbara Forte

Matteo Salsa

Jacqueline Lansen

Mauro Angiolini

Daniela Ruggieri

Daniela Faiardi

Germano Bosisio

Daniele Donati

Ilaria Motto

Elena Casale

Lorenzo Pegrassi

Rosanna Eccel

Laura Buffa

Paolo Trifiro'

Paolo Trifiro′

Maria Grabriella Brasca

Roberto D'alessio

Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors

The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.

Pyrrolo[2,3-D]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors

The present invention relates to substituted isoxazolo-quinazolines which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular human MPS1 and PERK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them. 

Isoxazolo-quinazolines as modulators of protein kinase activity

Thiazolylphenyl-benzenesulfonamido derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors

Substituted pyrazolophenyl-benzenesulfonamide compounds of formula (I) are described, wherein m, R1, R2, R3, and R4 are defined in the description, which modulate the activity of protein kinases, These compounds find utility in treating diseases caused by deregulated protein kinase activity, such as cancer and cell proliferative disorders. 

Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents

3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. 

3,4-diarylpyrazoles as protein kinase inhibitors

Compounds which are sulfonamido 3,4-diarylpyrazole derivatives, or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is their use as prodrugs.

Sulfonamido derivatives of 3,4-diarylpyrazoles as protein kinase inhibitors

Pyrazolo quinazoline derivatives, process for their preparation and their use as kinase inhibitors

The present invention provides tricyclic indoles and (4,5-dihydro) indoles of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring A represents a fused pyrazole, pyridine or pyrimidine,means either simple or double carbon-carbon bond and R, Rand Rare as defined in the specification. Further objects of the invention are a process for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Cdc7 and AKT kinase activity, like cancer. 

Tricyclic indoles and (4,5-dihydro) indoles

Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

Compounds which are 2-amino-1,3-thiazole derivatives of formula (I)wherein R is a halogen atom, a nitro group, an optionally substituted amino group or it is a group, optionally further substituted, selected from i) straight or branched C&#x2013;Calkyl, C&#x2013;Calkenyl or C&#x2013;Calkynyl; ii) C&#x2013;Ccycloalkyl; iii) aryl or arylalkyl with from 1 to 8 carbon atoms within the straight or branched alkyl chain; Ris an optionally further substituted group selected from: i) straight or branched C&#x2013;Calkyl or C&#x2013;Calkenyl; ii) 3 to 6 membered carbocycle or 5 to 7 membered heterocycle ring; iii) aryl or arylcarbonyl; iv) arylalkyl with from 1 to 8 carbon atoms within the straight or branched alkyl chain; v) arylalkenyl with from 2 to 6 carbon atoms within the straight or branched alkenyl chain; vi) an optionally protected amino acid residue; or a pharmaceutically acceptable salt thereof; are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.

2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents

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Milan, Italy

Gabriella Traquandi