Vicuron Pharmaceuticals Inc.

Gabriella Romano

Romeo Ciabatti

Gianbattista Panzone

Gianpaolo Candiani

Sonia Maffioli

Anna Checchia

The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC&#x2014;CO&#x2014;R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH&#x2014; represents deacylated ramoplanin, any of its factors or ramoplanose. The compound of Formula (I) are obtained by reacting a carboxylic acid R&#x2014;COOH with deacylated ramoplanin, any of its factors or ramoplanose protected on the ornitine amino groups. New compounds wherein the hydrocarbon radical R is different form those characaterizing the ramoplanin and ramoplanose natural products and their tetrahydro-derivatives are calimed. The new compounds have the same or better antinfective activity, lower haemolytic effect and better tolerability profile than ramoplanin.

Growing community of inventors

Legnano, Italy

Gabriella Romano