Egyt Gyogyszervegyeszeti Gyar

Egis Gyogyszergyar

Egis Gyogyszergyar Rt.

Gabriella Rmos Nee Lassu

Agnes Kovacs Nee Palotai

Gabor Blasko

Ivan Beck

Geza Schneider

Andras Dietz

Ilma Dinnyes Nee Nagy

Lujza E Petocz

Ibolya Kosoczky

Eniko Szirt Nee Kiszelly

Edit Berenyi Nee Poldermann

Peter Gorog

Judit Kun

Elemer Jakfalvi

Elemer Jakflavi

The invention relates to a novel process for preparing 1-[/2S/-methyl-3-mercaptopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula I ##STR1## in which 1-[/2S/-methyl-3-thiocyanatopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula II ##STR2## is dissolved in an aqueous mineral acid, the solution obtained is diluted with water and the 1-[/2S/-methyl-3-carbamoylthiopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula III ##STR3## that forms is hydrolized with an aqueous solution of a base.

Process for preparing 1-[/2S/-methyl

The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). ##STR1## which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) ##STR2## in an inert solvent, in the presence of a catalyst, at a temperature of 50.degree. to 120.degree. C. under a pressure of 10.sup.5 to 10.sup.7 Pa. The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating derivative of (2S)-2-methyl-3-rhodanido-propionic acid of formula (III). ##STR3##

Process for preparing 1-(2S)-3-mercapto-methyl-1-oxopropyl)-L-proline

The invention relates to novel pyrazolo[1,5-c]quinazoline derivatives of the general formula I ##STR1## wherein R represents a hydrogen atom, a C.sub.1-4 alkyl group or an acyl group,

Pyrazolo[1,5-c]quinazoline derivatives and analgesic compositions

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Budapest, Hungary

Gabriella Rmos Nee Lassu