University of California

Gabriella Lopez

Peter J Kushner

C Anthony Hunt

Paul Webb

Renee Williard

The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters having an AP1 site linked to a reporter gene. Compounds capable of inducing or blocking expression of the reporter gene can thus be identified. The compounds may be further tested for the ability to modulate the standard estrogen response, as well.

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San Francisco, CA, United States of America

Gabriella Lopez