Bracco Imaging S.p.a.

Gabriele Meli

Luciano Lattuada

Roberta Fretta

Fulvio Uggeri

Attilio Citterio

Massimo Visigalli

Gabriella Leonardi

Roberta Mazzon

Aurelia Ferrigato

Evelin Vignale

The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.

Manufacturing process for preparing gadoteridol

The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. 

Process for the iodination of aromatic compounds

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Gonessa, Italy

Gabriele Meli