Genentech, Inc.

Gabriele Maria Schaefer

Mark X Sliwkowski

Germaine G Fuh

Lauric Haber

The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.

Anti-HER antibodies

Multispecific anti-HER antibodies

A novel member of the heregulin superfamily has been identified which is designated '&#x3b3;-HRG'. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. &#x3b3;-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of &#x3b3;-HRG nucleic acid for the recombinant production of &#x3b3;-HRG). &#x3b3;-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.

&#x3b3;-heregulin

Antibodies that bind gamma-heregulin

A novel member of the heregulin superfamily has been identified which is designated &ldquo;&ggr;-HRG&rdquo;. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. &ggr;-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of &ggr;-HRG nucleic acid for the recombinant production of &ggr;-HRG). &ggr;-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.

Gamma-heregulin

A novel member of the heregulin superfamily has been identified which is designated '.gamma.-HRG'. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. .gamma.-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of .gamma.-HRG nucleic acid for the recombinant production of .gamma.-HRG). .gamma.-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.

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San Francisco, CA, United States of America

Gabriele Maria Schaefer