Aziende Chimiche Riunite Angelini Francesco A.c.r.a.f. S.p.a.

Gabriele Magaro'

Guido Furlotti

Nicola Cazzolla

Giorgina Mangano

Maria Alessandra Alisi

Barbara Garofalo

Rosella Ombrato

Beatrice Garrone

Francesca Mancini

Alessandra Capezzone De Joannon

The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.

Antibacterial compounds

The present invention relates to the new use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta (GSK-3&#x3b2;) inhibitors and to their use in the treatment of GSK-3&#x3b2;-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; and (viii) epilepsies.

Use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Tricyclic indazole compound and its pharmaceutically acceptable salts of acid addition, use thereof, method and intermediates for preparing them, and a pharmaceutical composition containing them. The tricyclic indazole compound has the following general Formula (I): in which R, R, L, L, X, X, X, X, X, Y, W, m, and n have the meanings stated in the description. 

Tricyclic indazole compound, method of preparation and pharmaceutical composition containing it

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Ariccia, Italy

Gabriele Magaro'