Indena S.p.a.

Gabriele Fontana

Ezio Bombardelli

Paolo Morazzoni

Antonella Riva

Arturo Battaglia

Massimo Ronchi

Carla Manzotti

Andrea Giori

Aldo Cristoni

Andrea Guerrini

Enrico Mercalli

Ezio Bombarrdelli

Maria Grazia Allegri, Legal Representative

Cristian Samori

Eleonora Baldelli

Maria Luisa Gelmi

Bruno Gabetta

Cesare Ponzone

Andrea Gambini

Donato Pocar

Vincenzo Di Marzo

Giovanni Appendino

Giacomo Carenzi

Bruno Danieli

Renato Iori

Federico Gassa

Cristian Samori′

Samanta Cimitan

Ruggero Beretta

Maurizio Taddei

Salvatore Princiotto

Maria Luisa Univ' Degli Studi Di Milano Gelmi

Donato Univ' Degli Studi Di Milano Pocar

Andrea ICOCEA Guerrini

Elenora Baldelli

Arturo ICOCEA Battaglia

Pocar Donato

The invention discloses a process for the preparation of maytansinoid esters of formula (I) comprising a thiol or disulphide group wherein R, Rand Rand the asterisk are as defined in the description, by reacting maytansinol with an enantiopure alpha-azido acid, followed by reduction of the azido group and reacting the obtained amino-ester with a compound of formula (IX) (IX) R&#x2014;S&#x2014;S&#x2014;X&#x2014;COOH wherein X and Rare as defined in the description, or with a reactive derivative thereof and optionally reducing the obtained disulfide-containing maytansinoid ester to give a maytansinoid ester wherein Ris a &#x2014;X&#x2014;SH group. 

Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof

Disclosed is a compound having the formula a) or b); a: R=CH; b: R=CHCH, and its use in the prevention and/or treatment of Alzheimer's disease. 

Hyperforin derivatives and their use in Alzheimer's disease

The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.

Formulations with sanguinarine, chelerythrine or chelidonine for the treatment of warts, verrucas and psoriatic plaques

Formulations containing sanguinarine or chelerythrine or the salts thereof or extracts containing them in admixture with suitable carriers and/or excipients for the treatment and/or prevention of mucositis.

Formulations for the treatment of mucositis induced by antitumor or immunosuppressive therapy

The invention concerns the use of glucomoringin and of its des-thio-glucoside having the following formulae (I, II): for the preparation of a medicament for the treatment of myeloma. 

Use of isothiocyanate derivatives as anti-myeloma agents

This invention relates to a 'one pot' process for the preparation of isoserine derivatives in high diastereoselective way. The process according to the invention includes the steps of reacting a protected glycidic acid with imines to yield isoserines protected both at the &#x2014;OH and at the &#x2014;COOH groups, deprotection of the obtained intermediates to isoserines or isoserine 1-4C&#x2014; alkyl esters. Pure threo derivatives as the main isomer are obtained.

Process for the preparation of isoserine derivatives

The present invention relates to compositions comprising benzophenanthridine alkaloids, benzofuran compounds and catechin polyphenols, which are useful in the treatment and prevention of infections of the oral cavity.

Compositions for the treatment and prevention of infections of the oral cavity

The use of benzophenanthridine alkaloids and the salts thereof for the preparation of medicaments for the treatment of tumors is disclosed.

Antitumoral agents with a benzophenanthridine structure and formulations containing them

A process for the preparation of 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) 

Semisynthesis process for the preparation of 10 deacetyl-N-debenzoyl-paclitaxel

The invention relates to a process for cosmetic treatment, including the reduction of superficial and deep wrinkles, using ferutinine fromspp extracts.

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Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.

Camptothecin derivatives with antitumor activity

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Milan, Italy

Gabriele Fontana