Bayer Aktiengesellschaft

Gabriele Braunlich

Mazen Es-Sayed

Graham Sturton

Rudiger Fischer

Rudolf H Hanko

Trevor S Abram

Mary F Fitzgerald

Stephen Richard Tudhope

Wendy J McDonald-Gibson

Graham Holmwood

Klaus-Helmut Mohrs

Michael Sperzel

Peter Norman

Rolf Henning

Ulrich Nielsch

Graham A Place

Roderick L Hall

Burkhardt Fugmann

Steve Tudhope

John-Edward Butler-Ransohoff

Heterocyclyclcarbonyl substituted benzofuranyl-ureas are prepared by reacting heterocyclylcarbonyl substituted 3-amino-benzofuranes with appropriate isocyanates or isothiocyanates. The unsubstituted ureas are transferred into substituted ureas by usual methods of substitution. The heterocyclylcarbonyl substituted benzofuranyl-ureas are useful as active ingredients in medicaments particularly for the treatment of acute and chronical inflammatory processes.

Heterocyclylcarbonyl substituted benzofuranyl-ureas

Heterocyclylcarbonyl substituted benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives are prepared by reacting appropriately substituted hydroxybenzene butanoic acid esters with heterocyclic ketones. The inventive compounds can be used for the preparation of medicaments, particularly of medicaments for the treatment and prevention of acute and chronic inflammatory processes.

Heterocyclylcarbonyl substituted benzofuranyl- and

The invention relates to the use of substituted cyclopentane-diones and cyclopentane-triones for the preparation of medicaments which as chloride channel blockers are suitable for controlling airway diseases, secretory diarrhea and inflammatory diseases.

Use of substituted cyclopentane- di- and -triones

The inventive Oxalylamino-benzofuran- and benzothienyl-derivatives are prepared by reacting the appropriate amino substituted benzofuranes and benzothiophenes with oxalic acid derivatives. The inventive compounds are suitable for the prevention and treatment of acute and chronic inflammatory processes, particularly of the airways.

Oxalylamino-benzofuran- and benzothienyl-derivatives

The Benzofuranyl- and -thiophenyl-alkane-carboxylic acid derivatives are prepared Tby cyclisation of hydroxy acetophenones and related compounds or by Wittig-reaction of benzofuranyl aldehydes. The compounds can be used to prepared medicaments.

Benzofuranyl-and-thiophenyl-alkanecarboxyclic acid derivatives

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Wuppertal, Germany

Gabriele Braunlich