Aptevo Research and Development LLC

Alligator Bioscience Ab

Aptevo Reserch and Development LLC

Gabriela Hernandez-Hoyos

David Bienvenue

Danielle Mitchell

John W Blankenship

Catherine J McMahan

Elaine Todd Sewell

Peter Pavlik

Christina Furebring

Peter Ellmark

Laura Von Schantz

Sara Fritzell

Laura Varas

Lynda Misher

Anna Sall

Danielle Van Citters

The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

CD123 binding proteins and related compositions and methods

The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.

Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods

Oncofetal antigen binding proteins and related compositions and methods

Methods of treatment of CD123 overexpressing disorders

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Seattle, WA, United States of America

Gabriela Hernandez-Hoyos