Regenerx Biopharmaceuticals, Inc.

The United States of America as Represented by the Secretary of Health

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Gabriel Sosne

Allan L Goldstein

Hynda K Kleinman

Katherine M Malinda

David Crockford

Michelle Wheater

A method of treatment for treating, at least partly preventing, inhibiting or reducing tissue deterioration, injury or damage due to a periodontal disease or disease of oral mucosa, or for restoring tissue adversely affected by the disease, in a subject, and/or for downregulating NF-kappaB or suppressing NF-kappaB mediated action in a body, organ, tissue or cell, includes administering to a subject, body, organ, tissue or cell an effective amount of a composition including a peptide agent including at least one of Thymosin beta 4 (T&#x3b2;4), an isoform of T&#x3b2;4, an N-terminal fragment of T&#x3b2;4, a C-terminal fragment of T&#x3b2;4, T&#x3b2;4 sulfoxide, an LKKTET peptide or conservative variant thereof, an LKKTNT peptide or conservative variant thereof, a KLKKTET peptide or conservative variant thereof, an LKKTETQ peptide or conservative variant thereof, T&#x3b2;4, T&#x3b2;9, T&#x3b2;10, T&#x3b2;11, T&#x3b2;12, T&#x3b2;13, T&#x3b2;14, T&#x3b2;15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DnaseI, vilin, fragmin, severin, capping protein, &#x3b2;-actinin, acumentin, an actin-sequestering peptide, an actin binding peptide, an actin-mobilizing peptide, an actin polymerization-modulating peptide, or a stimulating agent that stimulates production of an effective amount of the peptide agent in the subject, body, organ, tissue or cell.

Method of treating or preventing tissue deterioration, injury or damage due to periodontal disease or disease of oral mucosa, and/or downregulating NF-kappabeta or supressing NF-kappabeta-mediated actions

A composition including a peptide agent including amino acid sequence LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2], a conservative variant thereof, or a stimulating agent that stimulates production of an LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2] peptide, or a conservative variant thereof, the composition including at least one amino acid stabilizing agent or lyophilization bulking agent, the composition being in lyophilized form, or in a form capable of being lyophilized.

LKKTET and/or LKKTNT peptide compositions which are lyophilized or in a form capable of being lyophilized

Compositions and methods for treatment of skin utilizing thymosin &#x3b2;4.

Treatment of skin, and wound repair, with thymosin beta 4

A composition with a polypeptide including amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, the composition further including a carrier for application to a surface of a body.

Growing community of inventors

Oak Park, MI, United States of America

Gabriel Sosne