Antares Pharma Ipl Ag

Gabriel Porto

Dario Carrara

Jorge Rodriguez

A pharmaceutical composition in the form of a solution, cream, lotion, spray, ointment, gel, aerosol, tablet, suppository or patch device for transdermal or transmucosal administration of alprazolam to a subject, which includes as a permeation enhancing mixture a fatty component in an amount of 0.1% to 20% by weight which is one of (a) a saturated fatty alcohol of formula CH&#x2014;(CH)&#x2014;CHOH, a saturated fatty acid of formula CH&#x2014;(CH)&#x2014;CHCOOH, (b) an unsaturated fatty alcohol of formula CH(CH)&#x2014;OH, or (c) a fatty acid of formula CH(CH)&#x2014;COOH, wherein n is an integer of between 8 and 22; and a vehicle that includes a C-Calkanol, a polyalcohol, and water.

Composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels

The present invention refers to a pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of: a) saturated fatty alcohol of formula CH&#x2014;(CH)&#x2014;CHOH or saturated fatty acid CH&#x2014;(CH)&#x2014;CHCOOH wherein n is an integer number 8&#xf7;22, preferably 8&#xf7;12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula: CH(CH)&#x2014;OH or CH(CH)&#x2014;COOH wherein n is an integer number 8&#xf7;22, b) a ternary vehicle or carrier consisting of a C&#xf7;Calkanol, a polyalcohol in particular propylenglycol and water, c) optionally also a monoalkylether of diethylenglycol.

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Basel, Switzerland

Gabriel Porto