University of Michigan

The University of Chicago

Arch Development Corporation

Gabriel Nunez

Naohiro Inohara

Yasunori Ogura

Craig B Thompson

Lawrence H Boise

Jon Oscherwitz

Yumi Nakamura

Yun-Gi Kim

Tyler Nygaard

Kemp B Cease

Cathryn R Nagler

Kemp Cease

Judy Cho

Dan L Nicolae

Denise Bonen

Takeyoshi Koseki

Cathyrn R Nagler

Materials and methods are provided for treatment and/or prevention of Staphylococcal diseases and disorders such as infection and dermal inflammation.

Treatment of staphylococcal disorders

Provided herein are compositions and methods for the inhibition of enteric infection. In particular, compositions comprising bacteria of the class Clostridia are administered to human and/or animal subjects to prevent or decrease susceptibility to enteric infection.

Inhibition of enteric infection through the modulation of microbiota

Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (PSMA)

The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.

Nod2 nucleic acids and proteins

The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction. The present invention also provides Nod2 variant alleles. The present invention further provides methods of identifying individuals at increased risk of developing Crohn's disease.

The invention generally relates to compositions and methods for identifying Apoptosis signaling pathway inhibitors and activators.

Compositions and methods for identifying apoptosis signaling pathway inhibitors and activators

The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

Vertebrate apoptosis gene: compositions and methods

Growing community of inventors

Ann Arbor, MI, United States of America

Gabriel Nunez