Hoffmann-la Roche Inc.

Harbor Branch Oceanographic Institution, Inc.

University of California

Harbor Branch Oceanographic Inst. Inc.

Gabriel G Saucy

Noal Cohen

Ka-Kong Chan

Michael Rosenberger

Gary L Olson

John William Scott

Ka-kong Chan

David Richard Parrish

Robert S Jacobs

Oliver J McConnell

Sarath P Gunasekera

Ross E Longley

Neal S Burres

Steve Coval

Ranjit C Desai

Geewananda P Gunawardana

Richard D Wood

A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, hamacanthins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.

Use for bis-heterocyclic compounds and pharmaceutical compositions

A novel use for the class of biologically active bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.

Use for topsentin compounds and pharmaceutical compositions containing

This invention relates to the methods for the synthesis and use of acetylenic carbinols and their analogs, having various immunomodulatory properties in vitro and in vivo.

Synthesis of compounds with biological activity, and methods of use

An asymmetric synthesis for Vitamin E in an optically active pure form for 4-(2,5-diloweralkanoyloxy)-3,4,6-trimethylphenyl-butan-2-one and intermediates therein.

Asymmetric synthesis of natural vitamin E

Asymmetric synthesis of natural vitamin E.

Quinone intermediates for asymmetric synthesis of natural vitamin E

Natural Vitamin E intermediate

Natural vitamin E intermediate

A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.

Synthesis of vitamin E and quinone intermediates

A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta.-hydroxy-isobutyric acid including intermediates in this synthesis.

Synthesis of 2,6,10-trimethyl-undecan-1-ol

1 A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.

Synthesis of vitamin E

A process for producing vitamin A esters, vitamin A aldehyde and vitamin A acid esters from esters of 3,7-dimethyl-9-(1-hydroxy-2,2,6-trimethylcyclohexyl)-nona-2,4,6-trien-8-yn -1-ol and 3,7-dimethyl-9-(1-hydroxy-2,2,6-trimethylcyclohexyl)-nona-2,4,6-trien-8-yn oic acid including intermediates in this process.

Process for producing vitamin A

Growing community of inventors

Vero Beach, FL, United States of America

Gabriel G Saucy