University of Michigan

University Court of the University of St. Andrews

Gabriel Cooper Spalding

David J Mooney

William Leo Murphy

Kishan Dholakia

Michael Peter MacDonald

David H Kohn

Steven Leonard Neale

Matthew T Dearing

A fractionation system comprising means for forming a three dimensional optical lattice that is operable to separate particles that have different physical characteristics. Preferably, the wells of the optical lattice are interlinked. For example, the wells may be linked in such a manner as to provide deflection greater than or equal to 15 degrees.

Fractionation of particles

Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.

Mineral and cellular patterning on biomaterial surfaces

Growing community of inventors

Bloomington, IL, United States of America

Gabriel Cooper Spalding