Institute of Organic Chemistry and Biochemistry Ascr, V.v.i.

Gabriel Birkus

Ondrej Pav

Ivan Rosenberg

Ondrej Simak

Radim Nencka

Tomas Jandusik

Petra Brehova

Milan Dejmek

Michal Sala

Ondrej Kostov

Martin Maxmilian Kaiser

The present disclosure relates to 2'3′ cyclic phosphonate dinucleotides of Formula (I), the pharmaceutically acceptable salts, pharmaceutical composition and combinations of the substances and other medicaments or pharmaceuticals. The disclosure also relates to the compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases.

2'3′-cyclic dinucleotides and prodrugs thereof

The present disclosure relates to 3'3&#x2032;-cyclic dinucleotides having a carbocyclic nucleotide and derivatives that can modulate the activity of the STING adaptor protein.

3'3&#x2032;-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator

The present invention relates to 3'3&#x2032;-cyclic dinucleotides modified with a 3&#x2032;-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.

3'3&#x2032;-cyclic dinucleotides

The present disclosure relates to 2'3&#x2032; cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

2'3&#x2032; cyclic dinucleotides with phosphonate bond activating the sting adaptor protein

The present disclosure relates to 2'3&#x2032;-cyclic dinucleotides modified with a 2&#x2032;- or 3&#x2032;-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.

2'3&#x2032;-cyclic dinucleotides

Provided herein are the 3'3&#x2032; cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

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Prague, Czechia

Gabriel Birkus