Richter Gedeon Vegyeszeti Gyar Rt

Gabor Szepesi

Maria Gazdag

Geza Takacsi Nagy

Tibor Keve

Bela Stefko

Ferenc Trischler

Erik Bogsch

Lajos Kovacs

Laszlo Nagy

Gabor Megyeri

Kalman Burger

Emilia Simonovits

Andras Selmeczi

Pal Putz

Katalin Ranky Nee Szita

Takacsi Nagy

Andras Kelen

Szikla Z Papp

Eva E Kiss

Gyorgy Hangay

Bobjak M Zsoldos

Zsofia Papp Nee Sziklay

Andras Gulyas

Anna Kassia Nee Zieger

Judit Vincze Nee Kutrovics

Peter Keseru

The invention relates to novel, parenterally useful, stable aqueous pharmaceutical compositions, mainly injectable solutions containing a bis-indole alkaloid. The compositions contain the zinc complex of a bis-indole alkaloid, preferably vincristine, vinblastine or 5'-nor-dihydrovinblastine together with a bivalent metal gluconate and a preserving agent dissolved in a mono- or polyhydric alcohol. The invention further relates to a process for the preparation of the above compositions. The composition according to the invention can be utilized for the parenteral administration of bis-indole alkaloids in the cancer chemotherapy.

Stable parenteral compositions of vinblastine or vincristine

The invention relates to a novel cosmetic and paramedicinal active ingredient composition, particularly with an antiinflammatory and skin-calming effect, which comprises

Cosmetic and paramedicinal compositions containing plant extracts

The invention relates to a novel process for the halogenation in 2-position of ergot alkaloids. The process is characterized by that as a halogenating agent a system consisting of dimethylsulfoxide, a trialkylhalosilane or triarylhalosilane and optionally a hydrogen halide is used.

Process for the preparation of 2-halogenated ergoline derivatives

The invention relates to new aqueous pharmaceutical compositions containing as active ingredient a pharmaceutically acceptable complex of a bis-indole compound with a bi- or multivalent metal ion in a therapeutically effective amount. The invention further relates to complexes formed between a bis-indole compound and a bi- or multivalent metal ion. According to another aspect of the invention there is provided a process for the preparation of a pharmaceutically acceptable metal complex of a bis-indole compound and optionally stable aqueous pharmaceutical compositions containing said metal complex, in which a solution of a bis-indole compound or a pharmaceutically acceptable salt thereof in an aqueous medium is reacted with a non-toxic water soluble salt of a bi- or multivalent metal capable of complexation, at a pH of 3.0 to 6.0, optionally in the presence of or followed by the addition of a conventional pharmaceutical carrier and/or further additive, or, if desired, the obtained complex is isolated. The aqueous pharmaceutical compositions according to the invention have substantially increased stability.

Metal complexes of bis-indole compounds and aqueous pharmaceutical

A parenteral solvent suitable for injectable solutions of eburnamenines and dihydroeburnamenines is disclosed, said solvent containing a buffer having the ability to buffer the injectable solutions at given pH values, at least one stabilizing agent which includes parenterally acceptable aliphatic alcohols containing one or more hydroxy groups or water-miscible ethers thereof, 30 to 70% by weight water and optional preservatives, anaesthetics, and antioxidants.

Parenteral solvent and a process for the preparation of stable solutions

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Budapest, Hungary

Gabor Szepesi