Eastman Chemical Company

Li-cor, Inc.

Emory University

Eastman-kodak Company

Georgia State University Research Foundation, Inc.

Lahjavida, LLC

Gabor Patonay

James J Krutak

Max Allen Weaver

William W Parham

Michael R Cushman

Lyle R Middendorf

Clarence A Coates, Jr

Narasimhachari Narayanan

Lucjan Strekowski

Clarence A Coates

Maged M Henary

Malgorzata Lipowska

Michael John Cyr

James John Krutak, Sr

Lyle D Small

John A Brumbaugh

Leland W K Chung

Horst Clauberg

Ruoxiang Wang

Randy Barnett Meade

Isiah M Warner

James Edward Moore

Philip B Oldham

Haiyen E Zhau

Guodong Zhu

Xiaojian Yang

Chunmeng Shi

This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.

Cyanine-containing compounds for cancer imaging and treatment

Provided herein are heterocyclic near infrared compounds, including near IR compounds defined by Formulae I-V described herein. The near infrared compounds can include a cyanine group, a phthalocyanine group, a naphthalocyanine group, a squaraine group, a carbocyanine group, or a combination thereof. In some embodiments, the near infrared compound can be charged. In some embodiments, the near infrared compound can comprise a cationic group. Compositions comprising the near infrared compounds are also disclosed. In some embodiments, the composition can contain the near infrared compound, a polymer, and an acceptable carrier. In some embodiments, the polymer can include an anionic group. The compositions can be used as a coating for marking a surface, such as an ink. The compositions can also be used on articles for detecting, identifying, or authenticating the article. Methods of making the compositions described herein are also disclosed.

Near infrared absorbing fluorescent compositions

This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Au&#x2014;[CH(CH)CH&#x2014;(OCHCH)O]COCHCH-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

Method and dyes for detecting and destroying cancer cells

To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

Sequencing near infrared and infrared fluorescence labeled DNA for

An apparatus for detecting an invisible, near infrared fluorescing mark disposed on a background comprises: includes an excitation source for exciting the mark, having sufficient power to excite the mark and provide a fluorescent signal the mark from a; a signal detector for detecting the fluorescent signal from the mark; a and power modulator means for varying the power if the excitation source between zero and the maximum power level to produce a decodable fluorescent signal from the mark disposed on the background. A process for decoding an invisible mark having a near infrared fluorescing material includes the steps of: providing at least one invisible, near infrared fluorescing mark disposed on at least one portion of a background; exciting the mark with a laser having a maximum power level sufficient to provide a fluorescent signal from the mark; detecting the fluorescent signal and concurrently varying the power of the laser between zero and its maximum power, to obtain a decodable fluorescent signal.

Scanners for reading near infrared fluorescent marks

Provided are new compounds useful as near infrared fluorophoric markers. In the practice of this invention a method is also provided for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. The new compounds are phthalocyanine and naphthalocyanine derivatives which are covalently bonded to substituted silicon and aluminum compounds. The methods, compositions, and compounds described herein thus provide a total system useful for marking, for identification purposes, the various classes of thermoplastic wastes, so that they can be identified, sorted, and subsequently recycled.

Method for tagging thermoplastic materials with near infrared

To sequence DNA automatically, DNA marked with near infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a scanning light frequency within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission frequency of the marked DNA. The light is modulated from said laser at a predetermined modulation frequency and fluorescent light emitted by said DNA bands at said modulation frequency is detected, whereby background noise from the medium through which the light is transmitted is discriminated against.

Method for preparing fluorescent-labeled DNA

Sequencing near infrared and infrared fluorescense labeled DNA for

Provided is a method for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. Also provided is a method for identifying a thermoplastic container. Also provided are thermoplastic polymer compositions comprised of the near infrared fluorescing compounds or residues and articles comprised of such compositions.

Method for detecting and separating thermoplastic containers with near

Provided is a method for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. Also provided is a method for identifying a thermoplastic container. Also provided are thermoplastic polymer compositions comprised of the near infrared fluorescing compounds or residues and articles comprised of such compositions. Also provided are new compounds useful as near infrared fluorophoric markers in the practice of this invention. The methods, compositions, and compounds of the present invention thus provide a total system useful for marking, for identification purposes, the various classes of thermoplastic wastes, so that they can be identified, sorted, and subsequently recycled.

Provided are water-dissipatable, sulfo-containing polyesters and polyester-amides having copolymerized therein thermally stable near infrared flourophoric compounds. The polymers are useful in coating or ink compositions, which are in turn useful for marking articles for identification/authentication purposes. Also provided is a method for invisibly marking such articles and a method for detecting and sorting articles by utilizing the near infrared flourophoric ink or coating compositions.

Water-dissipatable polyesters and amides containing near infrared

Thermoplastic materials containing near infrared fluorophores

Growing community of inventors

Stone Mountain, GA, United States of America

Gabor Patonay