Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Gabor Kulcsar

Judit Frank

Gyula Dekany

Istvan Pelczer

Eniko Schreiner

Agoston David

Gyula Sebestyen

Gabor Horvath

Tibor Zilahi

Sandor Virag

Jeno Seres

Katalin Kaloy

Peter Sarkozy

Katalin Erdodine

Andras Kover

Arpad Buzna

Jeno Soltesz

Imre Szilagi

Tibor Valyl Nagy, Deceased

Gyula De Kany

Erika Varkonyi Nee Schlavicsko

Imre Szilagyi

Klara Beres Nee Palmai

Tamas Keresztes

Gergelyne P Katalin

The invention relates to a process for the preparation of water soluble primycin and to the separation of its components of formulae (A.sub.1) and (A.sub.3) either as single components or as a mixture of the two components. According to the invention

Process for the preparation of water soluble primycin and its components

The invention relates to antibacterial pseudo-primycin complexes of formula (I) ##STR1## to the components and acid addition salts thereof, as well as to the preparation of these compounds and to the pharmaceutical compositions containing said compounds as active ingredient. In the formula (I) R.sup.1 is butyl, pentyl or hexyl, R.sup.2 is hydrogen, hydroxyl or O-arabinose and X is organic or inorganic acid ion.

Process for the preparation of pseudo primycin

Pseudo-primycin complexes, components and acid addition salts thereof

The invention relates to the components of primycin antibiotic complex and the salts thereof and to the process for the separation of the individual components by chromatography. A further object of the invention is a synergistic antimicrobial composition containing the said components and a process for the preparation thereof.

Primycin components and process for the separation of the antibiotic

Pseudo-primycin complexes, components and acid addition salts thereof as

Process for the preparation of quinoline-carboxylic acid derivatives

The invention relates to a synergistic, antimicrobial pharmaceutical composition containing 0.01 to 50% by weight of a quinolinecarboxylic acid derivative or a naphthyridinecarboxylic acid derivative of the formula (I), ##STR1## wherein X is carbon or nitrogen;

Antimicrobial pharmaceutical composition

Oxypricin, a new antibiotic

This invention relates to new synergistic antimicrobial compositions containing primycin, doxycycline and sisomicin.

Synergistic antimicrobial compositions

A synergistic antimicrobial active ingredient for a pharmaceutical or veterinary composition comprises 5 to 50 percent by weight of a primycin component which consists of a primycin fermentation product of Thermonospora galeriensis and 95 to 50 percent by weight of at least one other component selected from the group which consists of doxycyline compounds and sisomicin compounds. The doxycycline compounds are selected from the group which consists of doxycycline, salts thereof with mineral acids, and doxycycline tryclate. The sisomicin compounds are selected from the group which consists of sisomicin, substituted sisomicins with substitution at the N atom by lower alkyl, hydroxyl lower alkyl, lower aminoalkyl and lower alkanoyl, and sisomicin acid salts.

A fungicidal compound of the formula: ##STR1## wherein A is C.sub.5-10 cycloalkyl, R is hydrogen, C.sub.1-6 alkyl, phenyl optionally substituted by one or more groups selected from C.sub.1-4 alkyl, nitro, hydroxy, carboxy, sulfo, sulfonylamino, halogen, C.sub.1-4 alkoxy, C.sub.1-4 acyloxy, C.sub.2-5 alkoxycarbonyl, C.sub.1-4 acyl, and N-(C.sub.2-5 alkoxycarbonyl)-sulfonylamino, or phenyl-(C.sub.1-4 alkyl) or a salt thereof.

1-Substituted-3-cycloalkyl-sulfonyl-pyrrolidine-2,5-dione derivatives

The antibiotic primycin synergizes the effect of other antibiotics when used together therewith in amounts such that the primycin constitutes 5 to 50% by weight of the total antibiotic content.

Synergistic antibiotic compositions

Growing community of inventors

Budapest, Hungary

Gabor Kulcsar