Richter Gedeon Vegyeszeti Gyar Rt

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Gabor Bernath

Laszlo Szporny

Eva Palosi

Gyorgy Hajos

Elemer Ezer

Laszlo Denes

Ferenc Fulop

Jeno Kobor

Istvan Hermecz

Jozsef Knoll

Zoltan Meszaros

Gabor Motika

Sandor Virag

Gabor Nagy

Peter Szentmiklosi

Zoltan Ecsery

Judit Hermann Nee Voros

Pal Sohar

Alajos Kalman

Janos Lazar

Ferenc Folop

Pal Perjesi

Attila Sohajda

Egon Karpati

Eva Somfai

Bela Kiss

Erzsebet Lapis

Zsolt Szombathelyi

Judit Laszy

Aniko Gere

Katalin Csomor

Adam Sarkadi

Sandor Szabo

Mihaly Bodo

Zoltan Torok

Matyas Szentivanyi

Laszlo Lazar

Zsolt Szentirmai

Erzsebet Janvari, Nee Kanyo

Gyorgy Gondos

Josef Knoll

Judit Arva

Imre Huber

Jen Kobor

Lajos Gera

Substituted oxazinoisoquinoline derivatives, pharmaceutical compositions

The invention relates to new 1-[6-(2'-substituted-5', 6', 7', 8'-tetrahydro-4'-oxo-quinazolino)]-3,4-dihydro-6,7-disubstituted-isoquinol ine derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each independently represents hdyroxyl or alkoxy having from 1 to 6 carbon atoms,

1-(6-(2'-substiuted-5', 6', 7',

The invention relates to new N-substituted bis(hydroxymethyl)-methyl-isoquinoline derivatives of the formula (I), ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

N-substituted isoquinoline derivatives and pharmaceutical compositions

The invention relates to new 1-[bis(hydroxymethyl)-methyl]-3,4-dihydro- or -1,2,3,4-tetrahydroisoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

Isoquinoline derivatives, and pharmaceutical compositions containing them

The invention relates to new bis(substituted methyl)-methyl-isoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

Bis(substituted methyl)-methyl-isoquinoline derivatives and

The invention relates to new [1,3]oxazino[4,3-a]-isoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

[1,3]oxazino[4,3-a]-isoquinoline derivatives and pharmaceutical

The invention relates to new 1-cyclohexyl-3,4-dihydroisoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each independently represents hydrogen, hydroxyl or alkoxy having from 1 to 6 carbon atoms,

1-cyclohexyl-3,4-dihydroisoquinoline derivatives and pharmaceutical

The invention relates to new 2H-azeto[2,1-a]isoquinoline derivatives of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

2H-azeto[2,1-a]-isoquinoline derivatives and pharmaceutical compositions

The invention relates to 1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2H,4H-[1,3]oxazino- or -thiazino-[4,3-a]isoquinoline derivatives of the formula (I), ##STR1## wherein R.sup.1 and R.sup.2 are alkoxy having from 1 to 6 carbon atoms,

1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2H,4H-[1,3]oxazino- or

Compounds of the formula ##STR1## or pharmaceutically acceptable acid-addition or quaternart ammonium salts thereof

Pyrido[1,2-A]pyrimidine derivatives and method of analgesic treatment

Pharmaceutical intermediates, morphine potentiators and other compounds have the formula ##STR1## wherein R is hydrogen, halogen, C.sub.1-4 alkyl, hydroxy, nitro, amino, carboxy or a carboxylic acid derivate radical, R.sup.1 is hydrogen or a C.sub.1-4 alkyl, R.sup.2 is hydrogen or C.sub.1-4 alkyl, R.sup.3 is hydrogen, R.sup.4 is hydrogen or C.sub.1-4 alkyl, R.sup.5 is hydrogen R.sup.6 is hydrogen or R.sup.3 and R.sup.4 and/or R.sup.5 and R.sup.6 form a chemical bond, X is oxygen or imino, m is 1, 2, 3 or 4, n is 0, 1, 2 or 3, and if n is 1, then the dotted lines can stand for bonds, with the proviso that if m=1 and n=1 and if in the 2,3-, 6,7-, 8,9- and 1,10-positions double bonds are present, and R.sup.1 and R.sup.2 are hydrogen, then R is other than 9-hydroxy or 9-methyl; if m=2 and n=1 and R.sup.2 is hydrogen, then at least one of R and R.sup.1 is other than hydrogen; and if m=2 and n=2 and R.sup.2 is hydrogen and the molecule is a 2,3,4,6,7,8,9,10-octahydro derivative, then at least one of R and R.sup.1 is other than hydrogen or an acid-addition or quaternary salt thereof.

2,3-Polymethylene-4-oxo-4H-pyrido[1,2-a]pyrimidines

Compounds of the formula: ##STR1## or pharmaceutically acceptable acid addition or quaternary ammonium salts thereof wherein

Pyrido[1,2-a]pyrimidine derivatives

A compound of the formula ##STR1## or a pharmaceutically effective salt thereof in which R.sup.1 and R.sup.2 are hydrogen or lower alkyl and R.sup.3 is halogenoalkenyl or propinyl. The compounds have pharmacological effects similar to those of phenylethylamine but are free from the amphetamine effect with an excellent therapeutic index and selectivity especially with respect to inhibition of monoaminooxidase.

N,N-Disubstituted-2-furylethyl amines

An antiedema compound of the formula: ##STR1## in which R.sup.1 is methyl, ethyl, cyclohexyl, phenyl, m-tolyl, p-tolyl, p-tert-butylphenyl, m-trifluoromethylphenyl, m-fluorophenyl, p-fluorophenyl, m-chlorophenyl, p-chlorophenyl, m-bromophenyl, p-bromophenyl, o-hydroxyphenyl, p-methoxyphenyl, p-nitrophenyl, benzyl, p-chlorobenzyl, m,p-dimethoxybenzyl, and o-pyridyl;

5,6-Dihydropyrimidin-4(3H)one derivatives, and antiedema compositions

Growing community of inventors

Szeged, Hungary

Gabor Bernath