Other

The Johns Hopkins University

G Steven Bova

Muniswamappa Anjanappa

William G Nelson

William B Isaacs

David T Bach

Srinivasan Yegnasubramanian

James J Bach

Steven L Paul

Martin Aryee

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.

DNA methylation markers for metastatic prostate cancer

A liquid storage and dispensing system, and methods for its use in the storage, shipping, and accurate dispensing by manual or automated methods, of, for example, precious biologic samples such as protein, DNA or RNA, with minimal contamination, oxidation, and evaporation, the system having: an essentially cylindrical storage barrel with a flange at its open end and a port and delivery tip at the closed end; a piston with a seal, where the piston closely matches the shape of the closed end of the barrel to minimize dead volume; and a cover to seal the delivery tip during storage such as cryostorage.

Long-term liquid storage and dispensing system

A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual cells thereby disrupting DNA, RNA and protein structure in those cells. The present invention produces a purified tissue section containing relatively intact DNA, RNA or protein from only the untreated cells. This purified sample is suitable for amplification of material by PCR or other techniques for the analysis of molecular genetic features in the selected cells of interest.

Laser cell purification system

A method of distributing research data from a common database to a user of the common database is provided. Data concerning research results and data upon which the research results are based are stored in a local database and are linked to each other. Data concerning research results and data upon which the research results are based are selectively extracted from the local database to the common database. Research data are then selected by a user of the common database from the extracted data concerning research results and from the data upon which the extracted data are based and the selected research data are distributed to the user.

Growing community of inventors

Baltimore, MD, United States of America

G Steven Bova