The General Hospital Corporation

Fuyixue Wang

Lawrence Leroy Wald

Kawin Setsompop

Hua Guo

Timothy G Reese

Zijing Dong

Systems and methods for magnetic resonance imaging ('MRI') that address the geometric distortions and blurring common to conventional echo planar imaging ('EPI') sequences, and that provide new temporal signal evolution information across the EPI readout, are described. Echo planar time-resolved imaging (&#x201c;EPTI&#x201d;) schemes are described to implement an accelerated sampling of a hybrid space spanned by the phase encoding dimension and the temporal dimension. In general, each EPTI shot covers a segment of this hybrid space using a zigzag trajectory with an interleaved acceleration in the phase-encoding direction. The hybrid space may be undersampled and a tilted reconstruction kernel used to synthesize additional data samples.

Method for echo planar time-resolved magnetic resonance imaging

Systems and methods for accelerated diffusion-weighted magnetic resonance imaging using a tilted reconstruction kernel to synthesize unsampled k-space data in phase encoded and point spread function ('PSF') encoded k-space data are provided. Images reconstructed from the data have reduced B-related distortions and reduced T* blurring. In general, data are acquired with systematically optimized undersampling of the PSF and phase encoding subspace. Parallel imaging reconstruction is implemented with a Binhomogeneity informed approach to achieve greater than twenty-fold acceleration of the PSF encoding dimension. A tilted reconstruction kernel is used to exploit the correlations in the phase encoding-PSF encoding subspace. Self-navigated phase corrections are computed from the acquired data and used to synthesize the unsampled k-space data.

Accelerated diffusion-weighted magnetic resonance imaging with self-navigated, phase corrected tilted kernel reconstruction of phase encoded and point spread function encoded k-space

Systems and methods for accelerated magnetic resonance imaging using a tilted reconstruction kernel to synthesize unsampled k-space data in phase encoded and point spread function ('PSF') encoded k-space data are provided. Images reconstructed from the data have reduced B-related distortions and reduced T* blurring. In general, data are acquired with systematically optimized undersampling of the PSF and phase encoding subspace. Parallel imaging reconstruction is implemented with a Binhomogeneity informed approach to achieve greater than twenty-fold acceleration of the PSF encoding dimension. A tilted reconstruction kernel is used to exploit the correlations in the phase encoding-PSF encoding subspace.

Growing community of inventors

Cambridge, MA, United States of America

Fuyixue Wang