Decibel Therapeutics, Inc.

Massachusetts Eye and Ear Infirmary

Accuredit Therapeutics (suzhou) Co., Ltd.

Fuxin Shi

John Lee

Qi-Ying Hu

John R Soglia

Albert Edge

Pengfei Hu

Songyuan Li

Han Qiu

Feifei Duan

Ke Qin

Huanle Liu

Jialin Tao

Provided herein are adenosine deaminases and variants thereof, nucleobase editors comprising deaminases, compositions comprising such editors, and methods of using such editors to generate modifications in target nucleobase sequences.

Deaminases and variants thereof for use in base editing

Hypertonic pharmaceutical compositions are disclosed. The hypertonic pharmaceutical compositions contain an anti-platinum chemoprotectant agent and a gelling agent. Also disclosed are methods of medical use of the hypertonic pharmaceutical compositions.

Hypertonic pharmaceutical compositions containing an anti-platinum chemoprotectant agent

Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof. Typically, the thiosulfate salt is administered to the subject scheduled to be administered a platinum-based antineoplastic agent within 4 hours. Alternatively, the thiosulfate salt is administered within 7 hours after the administration of a platinum-based neoplastic agent.

Methods of otoprotection against platinum-based antineoplastic agents

This disclosure relates to methods and compositions for modulating (e.g., increasing) Atoh1 activity (e.g., biological activity) and/or expression (e.g., transcription and/or translation) in vivo and/or in vitro, e.g., in a biological cell and/or in a subject. The methods and compositions described herein can be used in the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression in a biological cell.

Pathways to generate hair cells

Growing community of inventors

Winchester, MA, United States of America

Fuxin Shi