Kyorin Pharmaceutical Co., Ltd.

Futoshi Shiga

Yasuo Takano

Tsuyoshi Anraku

Kazunori Fukuchi

Yasumichi Fukuda

Yoshikazu Asahina

Masanori Takadoi

Tetsuya Kimura

Jun Asano

Kumi Ishikawa

Takahiro Kanda

Jyunichi Ishiyama

Tomoyuki Kawai

Hideharu Uchiki

Junichiro Uda

Novel intermediates for the production of aminoacetyl pyrrolidine carbonitrile derivatives ensure the safe and efficient production of the compounds. Specifically, the present invention provides a sulfonyloxyacetyl pyrrolidine derivative, represented by the following formula: (Chemical Formula 1) (wherein R1 is a substituted or unsubstituted C-Calkyl group, a substituted or unsubstituted C-Ccycloalkyl group, a substituted or unsubstituted arylmethyl group, a substituted or unsubstituted aromatic hydrocarbon, a substituted or unsubstituted aromatic heterocyclic ring or a substituted or unsubstituted aliphatic heterocyclic ring; R2 is CONHor CN; and X is CH, CHF or CF.)

Process for producing aminoacetyl pyrrolidine carbonitrile derivative and intermediate for production thereof

The invention provides 4-substituted aryl-5-hydroxyisoquinolinone derivatives and their pharmacologically acceptable addition salts with excellent inhibitory effect on poly (ADP-ribose) synthetase. 4-Substituted aryl-5-hydroxyisoquinolinone derivatives, represented by a general formula (1) and their pharmacologically acceptable addition salts.

4-(Substituted aryl)-5-hydroxyisoquinolinone derivative

6-subtituted-7-heteroquinoxalinecarboxylic acid derivatives and addition salts thereof and processes for the preparation of both

6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, addition salts thereof, and processes for the preparation of both

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Oyama, Japan

Futoshi Shiga