Kitazato Corporation

Kitazato Biopharma Co., Ltd.

St. Marianna University School of Medicine

The University of Tokyo

Kabushiki Kaisha Kitazato Supply

Natural Art Research Institute, Ltd.

Kitazato Bioscience Co., Ltd.

Kitazato Medical Co., Ltd.

Futoshi Inoue

Chie Inaba

Keiichi Kato

Kazuhiro Kawamura

Nao Suzuki

Masashige Kuwayama

Satoshi Ueno

Yodo Sugishita

Masashi Ikeuchi

Shokichi Teramoto

Masao Jinno

An intrauterine tissue collecting instrument includes a flexible outer tube, a flexible inner tube within the outer tube, and a shaft member within the inner tube. The flexible outer tube includes an outer tube distal end portion that can be open at at least three slits 4. The flexible inner tube includes an inner tube distal end portion including a plurality of side openings. The shaft member includes a diameter-expanded distal end portion. The intrauterine tissue collecting instrument can collect intrauterine tissue through suction in a state where the inner tube protrudes from the outer tube within the uterus. The inner tube distal end portion can be housed again in the flexible outer tube within the uterus.

Intrauterine tissue collection instrument

A cell cryopreservation pretreatment operation plate includes a planar operation portion, a first recess for storing a treatment solution, a second recess for storing a treatment solution, a third recess for storing a treatment solution, and a fourth recess for storing discarded solutions. The planar operation portion includes, on a surface thereof, a first circular segment, second circular segment, and third circular segment for placing treatment solutions, an enlarged first circular segment enclosing the first circular segment, an enlarged second circular segment enclosing the second circular segment, and an enlarged third circular segment enclosing the third circular segment.

Cell cryopreservation pretreatment operation plate

Tool for cryopreservation of biological cells

A living cell transplanting device has a flexible tube capable of accommodating living cells and a cell pushing shaft inserted into the tube. The tube has a lumen penetrating therethrough and a reduced diameter front end open portion. The shaft has a small diameter end portion having a diameter smaller than that of the reduced diameter front end open portion and an enlarged diameter portion having an outer diameter larger than an inner diameter of reduced diameter front end open portion. Owing to contact between the enlarged diameter portion of the shaft and the reduced diameter front end open portion of the tube, a progress of the shaft is regulated. By pushing the shaft into the tube after the contact between the enlarged diameter portion and the reduced diameter front end open portion finishes, the enlarged diameter portion of the shaft passes through said reduced diameter front end open portion with expanding the reduced diameter front end open portion of the tube and projects beyond the reduced diameter front end open portion of the tube.

Living cell transplanting tool

A culture medium protective liquid material of the present invention covers a culture medium when a living cell is cultured. The culture medium protective liquid material contains liquid paraffin which is liquid at room temperature as a main component thereof and an antioxidative substance for restraining the liquid paraffin from being oxidized.

Culture medium protective liquid material and embryo culture method

An instrument for fixedly transplanting a living body embryo into a uterus has an instrument, for transplanting the living body embryo into the uterus, which is to be inserted into a uterus and a magnetic embryo accommodation container holding instrument (transferred embryo fixing instrument) to be attached to the living body. The instrument for transplanting the living body embryo into the uterus has an embryo accommodation container having an embryo accommodation part having an embryo insertion portion communicating with outside and a magnetic material and a shaft-shaped container transfer tool for separably holding the embryo accommodation container at its distal end portion. The magnetic container holding instrument has an attaching part to be attached to an epidermis of the living body and a magnet capable of attracting the magnetic material of the embryo accommodation container thereto.

Instrument for fixedly transplanting living body embryo into uterus

A needle employs a three-stair-stepped structure including a front-end small diameter part, an intermediate part, and a large diameter part. The front-end small diameter part and the intermediate part are in fluid communication with each other by a first tapered part, and the intermediate part and the large diameter part are in fluid communication with each other by a second tapered part. The internal diameter of the front-end small diameter part is made so as to be equal to or greater than 0.35 mm based on the allowable deformation level of a cumulus oocyte complex, the outer diameter is made so as to be equal to or smaller than 0.7 mm based on the size of a small follicle, and the inclination angle of the inclined acicular end, and the length is made so as to be 10-25 mm based on the size of a dominant follicle.

Oocyte collection needle

A collected living tissue cryopreserving tool is composed of a tissue piece holder and a resin-made accommodating bag. The tissue piece holder is composed of a plate-shaped body part including a thermally conductive plate-shaped lower member and a plate-shaped upper member and a covering sheet held by the plate-shaped body part. The tissue piece holder has a tissue piece placing part formed of a cut-out part provided on the plate-shaped upper member and a part, of an upper surface of the thermally conductive plate-shaped lower member, which is disposed at the cut-out part. The covering sheet is capable of covering the tissue piece placing part.

Collected biological tissue cryopreservation tool and method for freezing collected tissue fragment

Medical tube hub

A blade tip-provided micropipette holding apparatus has a tubular micropipette holder so constructed that a blade tip-provided micropipette to be inserted into a living cell can be mounted on a front-end portion thereof and a holder-holding device for holding the micropipette holder. The holder-holding device has a base member and a tubular rotating member which is rotatably held by the base member and into which the tubular micropipette holder can be penetrated. The tubular rotating member has holder position adjusting mechanisms each composed of a plurality of side holes formed on a side surface of the tubular rotating member at different positions of the side surface thereof in a circumferential direction thereof and holder position adjusting members each capable of entering into the tubular rotating member from the side holes and contacting an outer surface of the micropipette holder penetrating through the tubular rotating member.

Blade tip-provided micropipette holding apparatus and intracytoplasmic sperm injection method

A living cell collection needle has a hollow needle having a hollow body part, a hollow small-diameter front end part, a tapered part between the front end part and the hollow body part and decreasing in inner and outer diameters toward the front end of the needle, and a piercing cutting edge part at a front end of the small-diameter front end part; a hub fixed to a rear end portion of the hollow body part; an inner tube inside the hollow needle and a living cell sucking tube connected to a rear end portion of the inner tube. A rear end of the hollow needle is positioned inside the hub. The needle has a side tube with a front end portion inside the hub and communicating with the inside of the hollow needle and a rear end portion projecting rearward from the hub and liquid-tightly fixed to the hub.

Living cell collection needle

A living cell cryopreservation tool has a body part formed of a cold-resistant material and a living cell holding part formed of the cold-resistant material. The living cell holding part has a long and narrow living cell attaching and holding portion. The living cell attaching and holding portion has a plurality of living cell accommodation concave portions formed in a longitudinal direction thereof and a plurality of excess cryopreservation liquid discharge passages communicating with the living cell accommodation concave portions.

Living cell cryopreservation tool

A living cell cryopreservation tool has a living cell holding member having a body part and a living cell holding part and a tubular accommodation member, closed at one end thereof, which is capable of accommodating the living cell holding member. The living cell holding part has a long and narrow living cell attaching and holding portion. The living cell attaching and holding portion has heat conductors extended in a longitudinal direction thereof and projected from a distal end thereof. The tubular accommodation member has a heat conductive member accommodated inside a distal portion thereof. When the living cell holding member is inserted into the tubular accommodation member from a distal side of each heat conductor thereof, a distal portion of each heat conductor contacts the heat conductive member of the tubular accommodation member.

A cell cryopreservation tool has a cell holding member having a body part and a cell holding part and a tubular accommodation member, closed at one end thereof, which is capable of accommodating the cell holding member. The cell holding part of the cell holding member has a long and narrow cell attaching and holding portion. The cell attaching and holding portion has a heat conductor extended in a longitudinal direction thereof. When the cell holding member is accommodated in the tubular accommodation member, the heat conductor is capable of contacting an inner surface of the tubular accommodation member.

Growing community of inventors

Fujinomiya, Japan

Futoshi Inoue