Sankyo Company, Limited

Fusaaki Shimizu

Norio Nakamura

Koichi Kitamura

Mitsuo Nagano

Kazuhiko Sasagawa

Takashi Matsui

Masao Arakawa

Hideki Miyazaki

Shigenobu Okuda

Shigeo Iwasaki

Michio Namikoshi

Amino acid amides of formula (I): ##STR1## wherein R.sup.1 -R.sup.5 and Y represent a variety of organic groups and atoms (including where R.sup.2, Y and the adjacent nitrogen atom together represent a thiazolidine or pyrrolidine group) and X represents carbonyl or sulfonyl are mostly new compounds and have valuable anti-tumor and immuno-regulatory activities. They may be formulated in compositions for pharmaceutical use.

Amino acid derivatives having anti-tumor activity and compositions

Compounds of formula (I): ##STR1## [wherein: m is 1-3; A and B are oxygen or sulfur; and one of R.sup.1 and R.sup.2 is C.sub.10 -C.sub.22 alkyl and the other is a group of formula (II). ##STR2## where: n is 2 or 3; and --NR.sup.3 R.sup.4 R.sup.5 is an amino group] and salts thereof are effective anti-cancer agents.

Certain tetrahydro-furan or pyran phosphate-ethylene or propylene

Acylated derivatives of rhizoxin and of rhizoxin-2-ene may be prepared by reacting rhizoxin or rhizoxin-2-ene with an acid or reactive derivative thereof. They have excellent anti-tumor activity.

Rhizoxin esters and salts, their pharmaceutical use as anti-tumor agents

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Hiromachi, Japan

Fusaaki Shimizu